Rabbit EDNRA / Endothelin A Receptor Polyclonal Antibody | anti-EDNRA antibody

Rabbit Polyclonal to Human EDNRA / Endothelin A Receptor

Cat. Num. AAA247684

• Gene Names: EDNRA; ETA; ET-A; ETAR; ETRA; ETA-R; hET-AR
• Reactivity: Gibbon, Gorilla, Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: EDNRA / Endothelin A Receptor; Polyclonal Antibody; Rabbit Polyclonal to Human EDNRA / Endothelin A Receptor; Anti-EDNRA / Endothelin A Receptor Antibody (N-Terminus) IHC-plus; EDNRA; Endothelin receptor subtype A; Et-a-r; ETRA; Endothelin A receptor; Endothelin eta receptor; Endothelin type a receptor; Endothelin-1 receptor; ETAR; Endothelin receptor type A; HET-AR; Et-a receptor; ETA; ETA-R; Human EDNRA; Endothelin A Receptor; anti-EDNRA antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human Endothelin A Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 427

• Applicable Applications for anti-EDNRA antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (16 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from N-terminal extracellular domain of human Endothelin A Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Marmoset (94%); Monkey, Sheep, Bat (89%).
• Immunogen Type: Synthetic peptide
• Immunogen: EDNRA / Endothelin A Receptor antibody was raised against synthetic 18 amino acid peptide from N-terminal extracellular domain of human Endothelin A Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Marmoset (94%); Monkey, Sheep, Bat (89%); Elephant, Dog, Bovine, Horse (83%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-Endothelin A Receptor antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-EDNRA antibody

The ETA receptor is an Endothelin Receptor that mediates the effects of endothelin-1, a mitogen with potent contractile properties. In the human fetal olfactory epithelium cell line FNC-B4, the ETA receptor increases the secretion of gonadotropin-releasing hormone. Increased ETA concentration may be correlated with smooth muscle hypertrophy observed in patients suffering from bladder-outlet obstruction.

Product Categories/Family for anti-EDNRA antibody

Family: GPCR; Subfamily: Endothelin

NCBI and Uniprot Product Information

• NCBI GI #: 4503465
• NCBI GeneID: 1909
• NCBI Accession #: NP_001948.1
• NCBI GenBank Nucleotide #: NM_001957.3
• UniProt Accession #: P25101; O43441; Q16432; Q16433; Q8TBH2; B2R723; B4E2V6; B7Z9G6; D3DP03; E7ER36; AAB24923
• Molecular Weight: 23,803 Da
• NCBI Official Full Name: endothelin-1 receptor isoform a
• NCBI Official Synonym Full Names: endothelin receptor type A
• NCBI Official Symbol: EDNRA
• NCBI Official Synonym Symbols: ETA; ET-A; ETAR; ETRA; ETA-R; hET-AR
• NCBI Protein Information: endothelin-1 receptor; G protein-coupled receptor; endothelin receptor subtype A; endothelin-1-specific receptor
• UniProt Protein Name: Endothelin-1 receptor
• Protein Family: Endothelin-1 receptor
• UniProt Gene Name: EDNRA
• UniProt Synonym Gene Names: ETA; ETRA; ET-A; ETA-R; hET-AR
• UniProt Entry Name: EDNRA_HUMAN

NCBI Description

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Uniprot Description

EDNRA: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q31.22

Cellular Component: nuclear membrane; integral to plasma membrane; T-tubule; plasma membrane; lipid raft

Molecular Function: endothelin receptor activity; protein binding; phosphoinositide phospholipase C activity

Biological Process: positive regulation of odontogenesis; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); neural crest cell development; metabolic process; heart development; response to morphine; smooth muscle cell proliferation; response to lipopolysaccharide; glucose transport; signal transduction; sensory perception of pain; enteric nervous system development; Rho protein signal transduction; regulation of epithelial cell proliferation; histamine secretion; negative regulation of cAMP biosynthetic process; elevation of cytosolic calcium ion concentration; smooth muscle contraction; fibroblast proliferation; regulation of blood pressure; positive regulation of cell proliferation; protein kinase C activation; artery smooth muscle contraction; penile erection; aging; vasoconstriction; in utero embryonic development; adenylate cyclase activation; glomerular filtration; respiratory gaseous exchange; patterning of blood vessels; G-protein coupled receptor protein signaling pathway; cell proliferation; phospholipase C activation; maternal process involved in parturition; response to hypoxia; positive regulation of protein amino acid phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of apoptosis; positive regulation of inflammatory response

Disease: Mandibulofacial Dysostosis With Alopecia; Migraine With Or Without Aura, Susceptibility To, 1