Western Blot (WB)
Rabbit EDG8 Polyclonal Antibody | anti-EDG8 antibody
EDG8 Antibody
Gene Names
S1pr5; Edg8; Edg-8
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot
Synonyms
EDG8; Polyclonal Antibody; EDG8 Antibody; EDG 8; Endothelial differentiation G protein coupled receptor 8; Endothelial differentiation sphingolipid G protein coupled receptor 8; S1P receptor 5; S1P receptor Edg 8; Sphingosine 1 Phosphate Receptor 5; Sphingosine 1-phosphate receptor Edg-8; SPPR2 antibody; anti-EDG8 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
Does not cross eact to other Spingosine 1-phosphate receptor subtypes. Labels a strong band of EDG8 of 48-50 kDa. Also labels a 54 kDa band, the identity of this is not known but may represent phosphorylated EDG8.
Form/Format
Affinity Purified
Concentration
0.52-0.63 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
400
Applicable Applications for anti-EDG8 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500
ELISA: 1:10,000
Western Blot: 1:500
Immunogen
Synthetic peptide taken within amino acid region 380-400 of rat S1P5R/EDG8 protein.
Expression
Found almost exclusively in brain and skin. Ubiquitously detected in different brain regions with very prominent expression in lower brain regions such as the midbrain, pons, medulla, and spinal cord. Expressed predominantly within white matter tracts of
Molecular Function
G-protein coupled receptor, Receptor, Transducer
Subcellular Location
Cell membrane; Multi-pass membrane protein
Preparation and Storage
-20 degree C for long term storage
Western Blot (WB)
Western Blot (WB)
Related Product Information for anti-EDG8 antibody
Affinity Purified Sphingosine 1-phosphate receptor 5 Antibody
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G-proteins.
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G-proteins.
Product Categories/Family for anti-EDG8 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
42,369 Da
NCBI Official Full Name
Sphingosine 1-phosphate receptor 5
NCBI Official Synonym Full Names
sphingosine-1-phosphate receptor 5
NCBI Official Symbol
S1pr5
NCBI Official Synonym Symbols
Edg8; Edg-8
NCBI Protein Information
sphingosine 1-phosphate receptor 5
UniProt Protein Name
Sphingosine 1-phosphate receptor 5
UniProt Gene Name
S1pr5
UniProt Synonym Gene Names
Edg8; Nrg1; S1P receptor 5; S1P5; NRG-1; S1P receptor Edg-8
UniProt Entry Name
S1PR5_RAT
NCBI Description
G protein-coupled receptor for the lysolipid phosphoric acid mediator sphingosine 1-phosphate [RGD, Feb 2006]
Uniprot Description
EDG8: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins. May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Cellular Component: integral to membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity
Biological Process: regulation of neuron differentiation
Research Articles on EDG8
Similar Products
Product Notes
The EDG8 s1pr5 (Catalog #AAA544764) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The EDG8 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's EDG8 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Western Blot: 1:500. Researchers should empirically determine the suitability of the EDG8 s1pr5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EDG8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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