Western Blot (WB)
(Western blot analysis of EDEM1 expression in LO2 (A), HCT116 (B), HCC827 (C), rat spleen (D) whole cell lysates.)
Rabbit EDEM1 Polyclonal Antibody | anti-EDEM1 antibody
Anti-EDEM1 Antibody
Western Blot (WB)
(Western blot analysis of EDEM1 expression in LO2 (A), HCT116 (B), HCC827 (C), rat spleen (D) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of EDEM1 expression in LO2 (A), HCT116 (B), HCC827 (C), rat spleen (D) whole cell lysates.)
NCBI and Uniprot Product Information
Uniprot Description
EDEM1: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It lacks mannosidase activity. Belongs to the glycosyl hydrolase 47 family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 3p26.1
Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane
Molecular Function: protein binding; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; calcium ion binding; misfolded protein binding
Biological Process: ER-associated protein catabolic process; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; protein folding; unfolded protein response; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Research Articles on EDEM1
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Product Notes
The EDEM1 edem1 (Catalog #AAA8232867) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-EDEM1 Antibody reacts with Human, Mouse, Rat, Bovine, Monkey, Porcine, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's EDEM1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB (1/500 - 1/1000). Researchers should empirically determine the suitability of the EDEM1 edem1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EDEM1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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