Rabbit anti-Human EDARADD Polyclonal Antibody | anti-EDARADD antibody

EDARADD Polyclonal Antibody

Cat. Num. AAA3010787

• Gene Names: EDARADD; ED3; EDA3; ECTD11A; ECTD11B
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: EDARADD; Polyclonal Antibody; EDARADD Polyclonal Antibody; ECTD11A; ECTD11B; ED3; EDA3; anti-EDARADD antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: EDARADD polyclonal antibody detects endogenous levels of EDARADD protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 205

• Applicable Applications for anti-EDARADD antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant protein of human EDARADD
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using EDARADD antibody.)

Related Product Information for anti-EDARADD antibody

This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

NCBI and Uniprot Product Information

• NCBI GI #: 18152769
• NCBI GeneID: 128178
• NCBI Accession #: NP_542776.1
• NCBI GenBank Nucleotide #: NP_542776.1
• UniProt Accession #: Q8WWZ3
• Molecular Weight: 25kDa
• NCBI Official Full Name: ectodysplasin-A receptor-associated adapter protein isoform B
• NCBI Official Synonym Full Names: EDAR associated death domain
• NCBI Official Symbol: EDARADD
• NCBI Official Synonym Symbols: ED3; EDA3; ECTD11A; ECTD11B
• NCBI Protein Information: ectodysplasin-A receptor-associated adapter protein
• UniProt Protein Name: Ectodysplasin-A receptor-associated adapter protein
• Protein Family: Ectodysplasin-A receptor-associated adapter protein
• UniProt Gene Name: EDARADD
• UniProt Entry Name: EDAD_HUMAN

NCBI Description

This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

EDARADD: Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF- kappa-B. Defects in EDARADD are a cause of ectodermal dysplasia anhidrotic (EDA); also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 1q42.3

Cellular Component: cytoplasm

Biological Process: hair follicle development; cell differentiation; signal transduction; odontogenesis of dentine-containing teeth

Disease: Ectodermal Dysplasia 11a, Hypohidrotic/hair/tooth Type, Autosomal Dominant; Ectodermal Dysplasia 10a, Hypohidrotic/hair/nail Type, Autosomal Dominant; Ectodermal Dysplasia 10b, Hypohidrotic/hair/tooth Type, Autosomal Recessive; Ectodermal Dysplasia 11b, Hypohidrotic/hair/tooth Type, Autosomal Recessive