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Western Blot (WB) (Ectodysplasin A antibody (MBS5301345) used at 1 ug/ml to detect target protein.)

Rabbit Ectodysplasin A Polyclonal Antibody | anti-EDA antibody

Ectodysplasin A antibody

Gene Names
EDA; ED1; HED; EDA1; EDA2; HED1; ODT1; XHED; ECTD1; XLHED; ED1-A1; ED1-A2; EDA-A1; EDA-A2; STHAGX1
Reactivity
Human, Mouse, Rat, Dog
Applications
Western Blot
Purity
Affinity purified
Synonyms
Ectodysplasin A; Polyclonal Antibody; Ectodysplasin A antibody; Polyclonal Ectodysplasin A; Anti-Ectodysplasin A; ED1-A2; ED1; XLHED; EDA2; ED1-A1; EDA1; HED; XHED; EDA; anti-EDA antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Clonality
Polyclonal
Specificity
Ectodysplasin A antibody was raised against the middle region of EDA
Purity/Purification
Affinity purified
Form/Format
Lyophilized powder. Add 50ul distilled water for a 1mg/ml concentration of EDA antibody in PBS
Concentration
1 mg/ml (varies by lot)
Sequence Length
389
Applicable Applications for anti-EDA antibody
Western Blot (WB)
Application Notes
WB: 1 ug/ml
Biological Significance
EDA is a type II membrane protein that can be cleaved by furin to produce a secreted form. It belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
Cross-Reactivity
Human,Mouse,Rat,Dog
Immunogen
Ectodysplasin A antibody was raised using the middle region of EDA corresponding to a region with amino acids GPPGPPGPQGPPGLQGPSGAADKAGTRENQPAVVHLQGQGSAIQVKNDLS
Preparation and Storage
Store at 2-8 degree C for short periods. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Western Blot (WB)

(Ectodysplasin A antibody (MBS5301345) used at 1 ug/ml to detect target protein.)

Western Blot (WB) (Ectodysplasin A antibody (MBS5301345) used at 1 ug/ml to detect target protein.)
Related Product Information for anti-EDA antibody
Rabbit polyclonal Ectodysplasin A antibody raised against the middle region of EDA
Product Categories/Family for anti-EDA antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
41 kDa (MW of target protein)
NCBI Official Full Name
Ectodysplasin A
NCBI Official Synonym Full Names
ectodysplasin A
NCBI Official Symbol
EDA
NCBI Official Synonym Symbols
ED1; HED; EDA1; EDA2; HED1; ODT1; XHED; ECTD1; XLHED; ED1-A1; ED1-A2; EDA-A1; EDA-A2; STHAGX1
NCBI Protein Information
ectodysplasin-A
UniProt Protein Name
Ectodysplasin-A
Protein Family
UniProt Gene Name
EDA
UniProt Synonym Gene Names
ED1; EDA2; EDA protein
UniProt Entry Name
EDA_HUMAN

NCBI Description

The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

EDA: Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR. Defects in EDA are the cause of ectodermal dysplasia type 1 (ED1); also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias. Defects in EDA are the cause of tooth agenesis selective X-linked type 1 (STHAGX1). A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). Belongs to the tumor necrosis factor family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: Xq12-q13.1

Cellular Component: endoplasmic reticulum membrane; collagen; cytoskeleton; membrane; intracellular membrane-bound organelle; integral to plasma membrane; apical part of cell; integral to membrane; extracellular region; plasma membrane

Molecular Function: protein binding; tumor necrosis factor receptor binding; receptor binding

Biological Process: pigmentation; cell-matrix adhesion; ectoderm development; gene expression; positive regulation of NF-kappaB import into nucleus; immune response; signal transduction; cell differentiation; activation of NF-kappaB transcription factor; odontogenesis of dentine-containing teeth

Disease: Tooth Agenesis, Selective, X-linked, 1; Ectodermal Dysplasia 1, Hypohidrotic, X-linked

Research Articles on EDA

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Product Notes

The EDA eda (Catalog #AAA5301345) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Ectodysplasin An antibody reacts with Human, Mouse, Rat, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's Ectodysplasin A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1 ug/ml. Researchers should empirically determine the suitability of the EDA eda for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ectodysplasin A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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