Rabbit anti-Human EB-1 / ANKS1B Polyclonal Antibody | anti-EB-1 antibody

Rabbit Polyclonal to Human EB-1 / ANKS1B

Cat. Num. AAA248107

• Gene Names: ANKS1B; EB1; AIDA; EB-1; ANKS2; AIDA-1; cajalin-2
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: EB-1 / ANKS1B; Polyclonal Antibody; Rabbit Polyclonal to Human EB-1 / ANKS1B; Anti-EB-1 / ANKS1B Antibody (aa570-599) IHC-plus; ANKS1B; AIDA-1; Cajalin-2; Cajalin 2; EB1; E2A-PBX1-associated protein; EB-1; ANKS2; Human EB-1; anti-EB-1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human EB-1 / ANKS1B, isoforms 1 and 6 of Q7Z6G8
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.09% sodium azide
• Sequence Length: 414

• Applicable Applications for anti-EB-1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (1:100), WB (1:1000)
• Target Species: Human
• Immunogen Description: KLH-conjugated synthetic peptide from internal region of human ANKS1B.
• Immunogen Type: Synthetic peptide
• Immunogen: EB-1 / ANKS1B antibody was raised against kLH-conjugated synthetic peptide from internal region of human ANKS1B.
• Antigen Modification: aa570-599
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Immunohistochemistry (IHC)

(Anti-EB-1 / ANKS1B antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-EB-1 / ANKS1B antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)

Western Blot (WB)

(ANKS1B Antibody (Center) Western blot of NCI-H292 cell line lysates (35 ug/lane). This demonstrates the ANKS1B antibody detected the ANKS1B protein (arrow).)

NCBI and Uniprot Product Information

• NCBI GI #: 10047134
• NCBI GeneID: 56899
• NCBI Accession #: NP_064525.1
• NCBI GenBank Nucleotide #: NM_020140.3
• UniProt Accession #: Q7Z6G8; Q5XLJ0; Q6IVB5; A5PKY5; A7E259; A8K153; A8MSN4; B4DFP6; B4DH98; F8VPM3; F8VZR9; F8WC27
• Molecular Weight: 44,522 Da
• NCBI Official Full Name: ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform c
• NCBI Official Synonym Full Names: ankyrin repeat and sterile alpha motif domain containing 1B
• NCBI Official Symbol: ANKS1B
• NCBI Official Synonym Symbols: EB1; AIDA; EB-1; ANKS2; AIDA-1; cajalin-2
• NCBI Protein Information: ankyrin repeat and sterile alpha motif domain-containing protein 1B; cajalin 2; E2a-Pbx1-associated protein; amyloid-beta precursor protein intracellular domain associated protein 1
• UniProt Protein Name: Ankyrin repeat and sterile alpha motif domain-containing protein 1B
• UniProt Gene Name: ANKS1B
• UniProt Synonym Gene Names: AIDA-1; EB-1
• UniProt Entry Name: ANS1B_HUMAN

NCBI Description

This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

AIDA-1b: Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 12q23.1

Cellular Component: Cajal body; postsynaptic membrane; cytoplasm; postsynaptic density; dendritic spine; cell junction

Molecular Function: ephrin receptor binding