Rabbit anti-Human, Mouse EARS2 Polyclonal Antibody | anti-EARS2 antibody

EARS2 Antibody

Cat. Num. AAA9434801

• Gene Names: EARS2; MSE1; gluRS; COXPD12
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: EARS2; Polyclonal Antibody; EARS2 Antibody; MSE1; gluRS; COXPD12; anti-EARS2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Purity/Purification: Antigen affinity purification
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 0.9mg/mL (varies by lot)

• Applicable Applications for anti-EARS2 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:100
• Immunogen: Synthetic peptide of human EARS2
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C for 1 year.

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using (EARS2 Antibody) at dilution 1/30.)

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using (EARS2 Antibody) at dilution 1/30.)

Related Product Information for anti-EARS2 antibody

This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants.

Product Categories/Family for anti-EARS2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 134288884
• NCBI GeneID: 124454
• NCBI Accession #: NP_001077083
• NCBI GenBank Nucleotide #: NM_001083614
• UniProt Accession #: Q8TBE9; Q5JPH6
• Molecular Weight: 59kDa
• NCBI Official Full Name: probable glutamate--tRNA ligase, mitochondrial isoform 1
• NCBI Official Synonym Full Names: glutamyl-tRNA synthetase 2, mitochondrial
• NCBI Official Symbol: EARS2
• NCBI Official Synonym Symbols: MSE1; gluRS; COXPD12
• NCBI Protein Information: probable glutamate--tRNA ligase, mitochondrial
• UniProt Protein Name: N-acylneuraminate-9-phosphatase
• Protein Family: Probable glutamate--tRNA ligase
• UniProt Gene Name: NANP
• UniProt Synonym Gene Names: C20orf147; HDHD4
• UniProt Entry Name: NANP_HUMAN

NCBI Description

This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Uniprot Description

HDHD4: Belongs to the HAD-like hydrolase superfamily. NANP family.

Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 3.1.3.29; Phosphatase (non-protein)

Chromosomal Location of Human Ortholog: 20p11.1

Cellular Component: cytosol

Molecular Function: N-acylneuraminate-9-phosphatase activity

Biological Process: N-acetylglucosamine biosynthetic process; N-acetylneuraminate biosynthetic process; cellular protein metabolic process; dephosphorylation; dolichol-linked oligosaccharide biosynthetic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification