Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using 860278(E2F7 Antibody) at dilution 1/60. (Original magnification: ×200))
Rabbit anti-Human E2F7 Polyclonal Antibody | anti-E2F7 antibody
E2F7 Rabbit pAb
Reactivity
Human
Applications
ELISA, Immunohistochemistry
Purity
Affinity purified
Synonyms
E2F7; Polyclonal Antibody; E2F7 Rabbit pAb; E2F transcription factor 7; anti-E2F7 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Purity/Purification
Affinity purified
Form/Format
pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Applicable Applications for anti-E2F7 antibody
ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)
Application Notes
ELISA: 1:1000-1:5000
IHC: 1:50-1:200
IHC: 1:50-1:200
Immunogen
Synthetic peptide of human E2F7
Conjugation
Unconjugated
Molecular Function
Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation.
Modification
Unmodified
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using 860278(E2F7 Antibody) at dilution 1/60. (Original magnification: ×200))
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using 860278(E2F7 Antibody) at dilution 1/60. (Original magnification: ×200))
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using 860278(E2F7 Antibody) at dilution 1/60.(Original magnification: ×200))
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using 860278(E2F7 Antibody) at dilution 1/60.(Original magnification: ×200))
Related Product Information for anti-E2F7 antibody
A typical E2F transcription factor that participates to various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. It plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3).
Product Categories/Family for anti-E2F7 antibody
NCBI and Uniprot Product Information
NCBI GeneID
UniProt Accession #
UniProt Protein Name
Transcription factor E2F7
Protein Family
UniProt Gene Name
E2F7
UniProt Entry Name
E2F7_HUMAN
Similar Products
Product Notes
The E2F7 e2f7 (Catalog #AAA4758247) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The E2F7 Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's E2F7 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P). ELISA: 1:1000-1:5000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the E2F7 e2f7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "E2F7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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