Rabbit anti-Human DYRK3 Polyclonal Antibody | anti-DYRK3 antibody

DYRK3, NT (Dual-specificity Tyrosine-phosphorylation Regulated Kinase 3, Regulatory Erythroid Kinase, REDK)

Cat. Num. AAA628496

• Gene Names: DYRK3; RED; REDK; DYRK5; hYAK3-2
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: DYRK3; Polyclonal Antibody; NT (Dual-specificity Tyrosine-phosphorylation Regulated Kinase 3; Regulatory Erythroid Kinase; REDK); Anti -DYRK3; anti-DYRK3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human DYRK3.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-DYRK3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:1,000; Western Blot: 1:100-1:500
• Immunogen: Synthetic peptide selected from the N-terminal region of human DYRK3 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of anti-DYRK3 Pab in Jurkat cell lysate. DYRK3 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.)

Related Product Information for anti-DYRK3 antibody

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.

Product Categories/Family for anti-DYRK3 antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 51702242
• NCBI GeneID: 8444
• NCBI Accession #: NP_001004023.1
• NCBI GenBank Nucleotide #: NM_001004023.1
• UniProt Accession #: O43781; Q7Z752; Q9HBY6; Q9HBY7; D3DT79; Q4G0U0; Q5SY34
• Molecular Weight: 65,714 Da
• NCBI Official Full Name: dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b
• NCBI Official Synonym Full Names: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
• NCBI Official Symbol: DYRK3
• NCBI Official Synonym Symbols: RED; REDK; DYRK5; hYAK3-2
• NCBI Protein Information: dual specificity tyrosine-phosphorylation-regulated kinase 3; OTTHUMP00000034527; OTTHUMP00000034528; OTTHUMP00000034529; OTTHUMP00000034530; protein kinase Dyrk3; regulatory erythroid kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5
• UniProt Protein Name: Dual specificity tyrosine-phosphorylation-regulated kinase 3
• Protein Family: Dual specificity tyrosine-phosphorylation-regulated kinase
• UniProt Gene Name: DYRK3
• UniProt Entry Name: DYRK3_HUMAN

NCBI Description

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Uniprot Description

DYRK3: a dual-specificity protein kinase of the DYRK family. Localizes in the cytoplasm. Expressed primarily in erythroid progenitor cells and regulates late erythropoiesis.

Protein type: EC 2.7.12.1; Protein kinase, dual-specificity (non-receptor); Kinase, protein; Protein kinase, CMGC; CMGC group; DYRK family; Dyrk2 subfamily

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: nucleus

Molecular Function: protein serine/threonine kinase activity; protein-tyrosine kinase activity; magnesium ion binding; protein serine/threonine/tyrosine kinase activity; ATP binding; protein kinase activity

Biological Process: peptidyl-tyrosine phosphorylation; erythrocyte differentiation; protein amino acid phosphorylation