Western Blot (WB)
(DYRK1B Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the DYRK1B antibody detected the DYRK1B protein (arrow).)
Rabbit DYRK1B Polyclonal Antibody | anti-DYRK1B antibody
DYRK1B Antibody (Center)
Western Blot (WB)
(DYRK1B Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the DYRK1B antibody detected the DYRK1B protein (arrow).)
Western Blot (WB)
(DYRK1B Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the DYRK1B antibody detected the DYRK1B protein (arrow).)
DYRK1B contains a bipartite nuclear localization signal and is
found mainly in muscle and testis. The protein is proposed to be
involved in the regulation of nuclear functions. Three isoforms of
DYRK1B have been identified differing in the presence of two
alternatively spliced exons within the catalytic domain. [provided
by RefSeq].
Yang, C., et al. Carcinogenesis 31(4):552-558(2010)
Jin, K., et al. J. Biol. Chem. 284(34):22916-22925(2009)
Deng, X., et al. Cancer Res. 69(8):3317-3324(2009)
Janumyan, Y., et al. J. Biol. Chem. 283(49):34108-34120(2008)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Description
DYRK1B: a dual-specificity protein kinase of the DYRK family. Localizes in the nucleus, where it enhances the transcriptional activity of TCF1/HNF1A. A co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. Induced by members of the Rho-family in myoblasts. Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. Contains a bipartite nuclear targeting signal sequence. Three splice-variant isoforms have been described.
Protein type: Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor); EC 2.7.12.1; Kinase, protein; CMGC group; DYRK family; Dyrk1 subfamily
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; transcription coactivator activity; protein serine/threonine/tyrosine kinase activity; ATP binding; protein kinase activity
Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; myoblast fusion
Disease: Abdominal Obesity-metabolic Syndrome 3
Research Articles on DYRK1B
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Product Notes
The DYRK1B dyrk1b (Catalog #AAA9203510) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 377-405. The DYRK1B Antibody (Center) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's DYRK1B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the DYRK1B dyrk1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DYRK1B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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