Western Blot (WB)
(Western blotAll lanes: Dynein light chain 1, cytoplasmic antibody at 2ug/ml+ EC109 whole cell lysateSecondaryGoat polyclonal to Rabbit IgG at 1/15000 dilutionPredicted band size: 9.8 kDaObserved band size: 9.8kDa)
Rabbit anti-Human Dynein light chain 1 Polyclonal Antibody | anti-DYNLL1 antibody
Rabbit anti-human Dynein light chain 1, cytoplasmic polyclonal Antibody
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Western Blot (WB)
(Western blotAll lanes: Dynein light chain 1, cytoplasmic antibody at 2ug/ml+ EC109 whole cell lysateSecondaryGoat polyclonal to Rabbit IgG at 1/15000 dilutionPredicted band size: 9.8 kDaObserved band size: 9.8kDa)
Western Blot (WB)
(Western blotAll lanes: Dynein light chain 1, cytoplasmic antibody at 2ug/ml+ EC109 whole cell lysateSecondaryGoat polyclonal to Rabbit IgG at 1/15000 dilutionPredicted band size: 9.8 kDaObserved band size: 9.8kDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human cervical cancer using MBS719552 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human cervical cancer using MBS719552 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS719552 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS719552 at dilution of 1:100)
Immunofluorescence (IF)
(Immunofluorescent analysis of MCF-7 cells using MBS719552 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Immunofluorescence (IF)
(Immunofluorescent analysis of MCF-7 cells using MBS719552 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
NCBI and Uniprot Product Information
NCBI Description
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
LC8: a highly conserved cytoplasmic protein of the dynein light chain family. Cytoplasmic dyneins are large enzyme complexes. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain. Interacts with and inhibits the activity of neuronal nitric oxide synthase (nNOS). A highly conserved protein, showing 92% amino acid similarity with the nematode homolog. Binding of this protein destabilizes the nNOS dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.
Protein type: Motor; Microtubule-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q24.23
Cellular Component: centrosome; cytoplasm; cytoplasmic dynein complex; cytosol; kinetochore; membrane; microtubule; mitochondrion; nucleus; plasma membrane; signalosome
Molecular Function: enzyme binding; motor activity; nitric-oxide synthase regulator activity; protein binding; protein C-terminus binding; protein domain specific binding; protein homodimerization activity
Biological Process: actin cytoskeleton organization and biogenesis; anatomical structure morphogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; apoptosis; cellular protein metabolic process; ER to Golgi vesicle-mediated transport; female gamete generation; G2/M transition of mitotic cell cycle; macroautophagy; mitotic cell cycle; negative regulation of phosphorylation; organelle organization and biogenesis; post-translational protein modification; programmed cell death; protein amino acid N-linked glycosylation via asparagine; regulation of catalytic activity; regulation of transcription, DNA-dependent; substantia nigra development; transcription, DNA-dependent; viral reproduction
Research Articles on DYNLL1
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Product Notes
The DYNLL1 dynll1 (Catalog #AAA719552) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Dynein light chain 1, cytoplasmic polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Dynein light chain 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the DYNLL1 dynll1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dynein light chain 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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