Rabbit anti-Human DUSP7 Polyclonal Antibody | anti-DUSP7 antibody

DUSP7, NT (Dual Specificity Protein Phosphatase 7, Dual Specificity Protein Phosphatase PYST2, PYST2) (APC)

Cat. Num. AAA6473189

• Gene Names: DUSP7; MKPX; PYST2
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A/G Affinity Chromatography.
• Synonyms: DUSP7; Polyclonal Antibody; NT (Dual Specificity Protein Phosphatase 7; Dual Specificity Protein Phosphatase PYST2; PYST2) (APC); anti-DUSP7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human DUSP7.
• Purity/Purification: Purified by Protein A/G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-DUSP7 antibody: Immunohistochemistry (IHC) Paraffin, FLISA, Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 96-127 in the N-terminal region of human DUSP7, Swiss/UniProt Accession: Q16829.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of DUSP7 (arrow) usingMBS629287. 293 cell lysates (2ug/lane) either Lane 1: nontransfected Lane 2: transiently transfected with the DUSP7 gene (Origene Technologies).)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis in formalin fixed and paraffin embedded human breast cancer tissue using MBS629287 followed by peroxidase conjugation of the secondary antibody and AEC staining. This data demonstrates the use of MBS629287 for immunohistochemistry.)

Product Categories/Family for anti-DUSP7 antibody

Antibodies; Enzymes; Phosphatase

References

1. Immunol. Lett. 92(1-2), 149-156 (2004). 2. Oncogene 22(48), 7649-7660 (2003). 3. Meth. Enzymol. 366, 103-113 (2003). 4. J. Cell. Sci. 111(PT 22), 3389-3399 (1998). 5. EMBO J. 15(14), 3621-3632 (1996).

NCBI and Uniprot Product Information

• NCBI GI #: 238231453
• NCBI GeneID: 1849
• NCBI Accession #: NP_001938
• NCBI GenBank Nucleotide #: NM_001947.3
• UniProt Accession #: Q16829; Q2M3J7; Q8NFJ0
• Molecular Weight: 40,551 Da
• NCBI Official Full Name: dual specificity protein phosphatase 7
• NCBI Official Synonym Full Names: dual specificity phosphatase 7
• NCBI Official Symbol: DUSP7
• NCBI Official Synonym Symbols: MKPX; PYST2
• NCBI Protein Information: dual specificity protein phosphatase 7
• UniProt Protein Name: Dual specificity protein phosphatase 7
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP7
• UniProt Synonym Gene Names: PYST2
• UniProt Entry Name: DUS7_HUMAN

NCBI Description

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]