Western Blot (WB)
(DUSP10 Antibody (Center) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the DUSP10 antibody detected the DUSP10 protein (arrow).)
Rabbit DUSP10 Polyclonal Antibody | anti-DUSP10 antibody
DUSP10 Antibody (Center)
Western Blot (WB)
(DUSP10 Antibody (Center) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the DUSP10 antibody detected the DUSP10 protein (arrow).)
Western Blot (WB)
(DUSP10 Antibody (Center) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the DUSP10 antibody detected the DUSP10 protein (arrow).)
target kinases by dephosphorylating both the
phosphoserine/threonine and phosphotyrosine residues. They
negatively regulate members of the MAPK superfamily (MAPK/ERK,
SAPK/JNK, p38), which is associated with cellular proliferation and
differentiation. Different members of this family of dual
specificity phosphatases show distinct substrate specificities for
MAPKs, different tissue distribution and subcellular localization,
and different modes of inducibility of their expression by
extracellular stimuli. This gene product binds to and inactivates
p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is
unique; it is evenly distributed in both the cytoplasm and the
nucleus. This gene is widely expressed in various tissues and
organs, and its expression is elevated by stress stimuli. Three
transcript variants encoding two different isoforms have been found
for this gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Tephly, L.A., et al. Am. J. Respir. Cell Mol. Biol. 39(1):113-123(2008)
Teng, C.H., et al. J. Biol. Chem. 282(39):28395-28407(2007)
NCBI and Uniprot Product Information
NCBI Description
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Description
MKP-5: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. Contains 1 rhodanese domain.
Protein type: EC 3.1.3.48; EC 3.1.3.16; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; nucleus
Molecular Function: MAP kinase phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity
Biological Process: negative regulation of oligodendrocyte differentiation; negative regulation of JNK cascade; negative regulation of JNK activity; regulation of adaptive immune response; response to stress; oligodendrocyte differentiation; JNK cascade; response to lipopolysaccharide; protein amino acid dephosphorylation; inactivation of MAPK activity
Research Articles on DUSP10
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Product Notes
The DUSP10 dusp10 (Catalog #AAA9206721) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 204-232. The DUSP10 Antibody (Center) reacts with Human (Predicted Reactivity: Bovine, Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's DUSP10 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the DUSP10 dusp10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DUSP10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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