Rabbit anti-Human Dual specificity tyrosine-phosphorylation-regulated kinase 2 Polyclonal Antibody | anti-DYRK2 antibody

Rabbit anti-human Dual specificity tyrosine-phosphorylation-regulated kinase 2 polyclonal Antibody(DYRK2)

Cat. Num. AAA1499986

• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 2; Polyclonal Antibody; Rabbit anti-human Dual specificity tyrosine-phosphorylation-regulated kinase 2 polyclonal Antibody(DYRK2); DYRK2; anti-DYRK2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Sequence Length: 528

• Applicable Applications for anti-DYRK2 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC:1:20-1:200
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Conjugate: Non-conjugated
• Immunogen: Recombinant human Dual specificity tyrosine-phosphorylation-regulated kinase 2 protein (502-601aa)
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-18951 / sc-31972 / sc-31974 / sc-66867
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon cancer using MBS1499986at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human testicle using MBS1499986 at dilution 1:100)

Related Product Information for anti-DYRK2 antibody

Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).

NCBI and Uniprot Product Information

• NCBI GI #: 4503427
• NCBI GeneID: 8445
• NCBI Accession #: NP_003574.1
• NCBI GenBank Nucleotide #: NM_003583.3
• UniProt Accession #: Q92630; Q9BRB5; B2R9V9
• Molecular Weight: 59,715 Da
• NCBI Official Full Name: dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 1
• NCBI Official Synonym Full Names: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2
• NCBI Official Symbol: DYRK2
• NCBI Protein Information: dual specificity tyrosine-phosphorylation-regulated kinase 2
• UniProt Protein Name: Dual specificity tyrosine-phosphorylation-regulated kinase 2
• Protein Family: Dual specificity tyrosine-phosphorylation-regulated kinase
• UniProt Gene Name: DYRK2
• UniProt Entry Name: DYRK2_HUMAN

NCBI Description

DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]

Uniprot Description

DYRK2: a dual-specificity protein kinase of the DYRK family. Localizes in the cytoplasm. Phosphorylates the translation initiation factor eIF2B at Ser539, priming it for phosphorylation by glycogen synthase kinase-3.

Protein type: Protein kinase, CMGC; EC 2.7.12.1; Protein kinase, dual-specificity (non-receptor); Kinase, protein; CMGC group; DYRK family; Dyrk2 subfamily

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: cytoplasm; nucleoplasm; nucleus; ribonucleoprotein complex; ubiquitin ligase complex

Molecular Function: ATP binding; magnesium ion binding; manganese ion binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein-tyrosine kinase activity; ubiquitin binding

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of NFAT protein import into nucleus; peptidyl-tyrosine phosphorylation; positive regulation of glycogen biosynthetic process; protein amino acid phosphorylation; response to DNA damage stimulus; smoothened signaling pathway