Rabbit DRD1 / Dopamine Receptor D1 Polyclonal Antibody | anti-DRD1 antibody

Rabbit Polyclonal to Human DRD1 / Dopamine Receptor D1

Cat. Num. AAA244461

• Gene Names: DRD1; DADR; DRD1A
• Reactivity: Gorilla, Human, Monkey; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: DRD1 / Dopamine Receptor D1; Polyclonal Antibody; Rabbit Polyclonal to Human DRD1 / Dopamine Receptor D1; Anti-DRD1 / Dopamine Receptor D1 Antibody (C-Terminus) IHC-plus; DRD1; D(1A) dopamine receptor; D1a dopamine receptor; Dopamine d-1 receptor; Dopamine receptor d1a; DRD1A; DADR; Dopamine d1a receptor; Dopamine receptor D1; Dopamine 1 receptor; Dopamine type 1 receptor; D-1 dopamine receptor; D1 dopamine receptor; Human DRD1; Dopamine Receptor D1; anti-DRD1 antibody

• Host: Rabbit
• Reactivity: Gorilla, Human, Monkey; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human DRD1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 446

• Applicable Applications for anti-DRD1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 - 10 ug/ml)
• Usage Not Recommended: Immunocytochemistry (ICC)
• Target Species: Human
• Immunogen Description: Synthetic 17 amino acid peptide from C-terminus of human DRD1. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Gibbon (94%); Rat, Elephant, Pig (88%); Sheep, Hamster, Panda, Bovine (82%).
• Immunogen Type: Synthetic peptide
• Immunogen: DRD1 / Dopamine Receptor D1 antibody was raised against synthetic 17 amino acid peptide from C-terminus of human DRD1. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Gibbon (94%); Rat, Elephant, Pig (88%); Sheep, Hamster, Panda, Bovine (82%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-DRD1 / Dopamine Receptor D1 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-Dopamine Receptor D1 / DRD1 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 7 ug/ml.)

Immunohistochemistry (IHC)

(Anti-DRD1 / Dopamine Receptor D1 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-DRD1 antibody

DRD1, a Dopamine Receptor, mediates the effect of the neurotransmitter dopamine, an intermediate in the biosynthesis of noradrenaline and adrenaline. It is involved in the control of motor activity and cognitive memory. Downregulation of DRD1 leads to severe impairments in working memory and to locomotor hyperactivity, which are observed in diseases such as schizophrenia, Parkinson's disease, affective disorders, and attention deficit hyperactivity disorder.

Product Categories/Family for anti-DRD1 antibody

Family: GPCR; Subfamily: Dopamine

NCBI and Uniprot Product Information

• NCBI GI #: 4503383
• NCBI GeneID: 1812
• NCBI Accession #: NP_000785.1
• NCBI GenBank Nucleotide #: NM_000794.3
• UniProt Accession #: P21728; Q4QRJ0; B2RA44
• Molecular Weight: 49,293 Da
• NCBI Official Full Name: D(1A) dopamine receptor
• NCBI Official Synonym Full Names: dopamine receptor D1
• NCBI Official Symbol: DRD1
• NCBI Official Synonym Symbols: DADR; DRD1A
• NCBI Protein Information: D(1A) dopamine receptor; D(1A) dopamine receptor; dopamine D1 receptor
• UniProt Protein Name: D(1A) dopamine receptor
• Protein Family: D(1A) dopamine receptor
• UniProt Gene Name: DRD1
• UniProt Entry Name: DRD1_HUMAN

NCBI Description

This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

DRD1: a G-protein coupled receptor.One of the five types (D1 to D5) of receptors for dopamine. The most abundant dopamine receptor in the central nervous system. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Interacts with calcyon.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; plasma membrane; nucleus

Molecular Function: protein binding; dopamine receptor activity; dopamine binding; dopamine D1 receptor-like receptor activity

Biological Process: synaptic transmission, dopaminergic; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); peristalsis; behavioral fear response; prepulse inhibition; positive regulation of potassium ion transport; generation of action potential; thermoregulation; vasodilation; positive regulation of synaptic transmission, glutamatergic; dopamine metabolic process; G-protein signaling, adenylate cyclase activating pathway; adult walking behavior; synaptogenesis; behavioral response to cocaine; protein import into nucleus; conditioned taste aversion; positive regulation of cAMP biosynthetic process; visual learning; dopamine receptor, adenylate cyclase activating pathway; response to drug; grooming behavior; dopamine transport; dentate gyrus development; cerebral cortex GABAergic interneuron migration; striatum development; maternal behavior; response to amphetamine; adenylate cyclase activation; regulation of dopamine metabolic process; mating behavior; regulation of dopamine uptake; transmission of nerve impulse; astrocyte development; memory; G-protein signaling, coupled to cyclic nucleotide second messenger; habituation; glucose import; operant conditioning; sensitization; positive regulation of release of sequestered calcium ion into cytosol; dopamine receptor, phospholipase C activating pathway; positive regulation of cell migration