Mouse anti-Human, Rat DPYSL5 Polyclonal Antibody | anti-DPYSL5 antibody

DPYSL5 (Dihydropyrimidinase-related Protein 5, DRP-5, CRMP3-associated Molecule, CRAM, Collapsin Response Mediator Protein 5, CRMP-5, UNC33-like Phosphoprotein 6, ULIP-6, CRMP5, ULIP6)

Cat. Num. AAA644697

• Gene Names: DPYSL5; CRAM; CRMP5; Ulip6; CRMP-5
• Reactivity: Human, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: DPYSL5; Polyclonal Antibody; DPYSL5 (Dihydropyrimidinase-related Protein 5; DRP-5; CRMP3-associated Molecule; CRAM; Collapsin Response Mediator Protein 5; CRMP-5; UNC33-like Phosphoprotein 6; ULIP-6; CRMP5; ULIP6); Anti -DPYSL5 (Dihydropyrimidinase-related Protein 5; anti-DPYSL5 antibody

• Host: Mouse
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human DPYSL5. Species Crossreactivity: rat.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MLANSASVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCCDYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGAIARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGGKMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREKTLKVRGVDRTPYLGDVAVVVHPGKKEMGTPLADTPTRPVTRHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSSGIW

• Applicable Applications for anti-DPYSL5 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human DPYSL5, aa1-564 (NP_064519.2).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(DPYSL5 polyclonal antibody. Western Blot analysis of DPYSL5 expression in rat brain.)

Western Blot (WB)

(Western Blot analysis of DPYSL5 expression in transfected 293T cell line by DPYSL5 polyclonal antibody. Lane 1: DPYSL5 transfected lysate (62.04kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-DPYSL5 antibody

The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus.

Product Categories/Family for anti-DPYSL5 antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 12804043
• NCBI GeneID: 56896
• UniProt Accession #: Q9BPU6; Q8TCL6; Q9NQC4; Q9NRY9
• Molecular Weight: 61,421 Da
• NCBI Official Full Name: DPYSL5 protein
• NCBI Official Synonym Full Names: dihydropyrimidinase-like 5
• NCBI Official Symbol: DPYSL5
• NCBI Official Synonym Symbols: CRAM; CRMP5; Ulip6; CRMP-5
• NCBI Protein Information: dihydropyrimidinase-related protein 5; DRP-5; ULIP-6; CRMP3-associated molecule; UNC33-like phosphoprotein 6; collapsin response mediator protein 5; collapsin response mediator protein-5
• UniProt Protein Name: Dihydropyrimidinase-related protein 5
• Protein Family: Dihydropyrimidinase-related protein
• UniProt Gene Name: DPYSL5
• UniProt Synonym Gene Names: CRMP5; ULIP6; DRP-5; CRAM; CRMP-5; ULIP-6
• UniProt Entry Name: DPYL5_HUMAN

NCBI Description

This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

Uniprot Description

CRMP-5: May have a function in neuronal differentiation and/or axon growth. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: cell soma; dendrite; cytosol

Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Biological Process: axon guidance; nervous system development; signal transduction; pyrimidine base catabolic process