Rabbit DPP6 Polyclonal Antibody | anti-DPP6 antibody

DPP6 Antibody FITC Conjugated

Cat. Num. AAA9461930

• Gene Names: DPP6; VF2; DPPX
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence
• Purity: Purified by Protein A
• Synonyms: DPP6; Polyclonal Antibody; DPP6 Antibody FITC Conjugated; Dipeptidyl aminopeptidase like protein 6; Dipeptidyl aminopeptidase related protein; Dipeptidyl peptidase 6; Dipeptidyl peptidase IV like protein; Dipeptidylpeptidase 6; Dipeptidylpeptidase VI; DPPX; DPP6_HUMAN; anti-DPP6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A
• Form/Format: 10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Concentration: 1mgml (varies by lot)

• Applicable Applications for anti-DPP6 antibody: Immunofluorescence (IF)
• Application Notes: IF: 1:50-200
• Conjugation: FITC
• Excitation Emission: 494nm 518nm
• Immunogen: KLH conjugated synthetic peptide derived from human DPP6
• Preparation and Storage: Store at 4 degree C for 12 months.

Related Product Information for anti-DPP6 antibody

DPP6 is a Type-II serine proteinase of the clan SC. The clan SC proteinases have a catalytic triad of Ser-Asp-His, and like other Serine proteinases, the active site serine is in a Gly-Xaa-Ser-Xaa -Gly orientation. DPP6 has an Asp instead of Ser in the catalytic site. DPP6 is a member of a broader family of dipeptidyl peptidases including DPP4, FAP Seprase, DPP2, DPP8, DPP9, DPP10, which have differing substrate specificity and tissue localizations. The surface-bound DPP6 is a homodimer, and cleavage of in the stalk region releases a shed form of DPP6. The shed is the form found in serum. DPP6 has been found in highest abundance in the brain, but also in the kidney, liver and lung.

Product Categories/Family for anti-DPP6 antibody

Conjugated Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 218512016
• NCBI GeneID: 1804
• UniProt Accession #: P42658
• Molecular Weight: 97,588 Da
• NCBI Official Full Name: Dipeptidyl aminopeptidase-like protein 6
• NCBI Official Synonym Full Names: dipeptidyl-peptidase 6
• NCBI Official Symbol: DPP6
• NCBI Official Synonym Symbols: VF2; DPPX
• NCBI Protein Information: dipeptidyl aminopeptidase-like protein 6; DPP VI; dipeptidyl peptidase VI; dipeptidyl peptidase IV-related protein; dipeptidyl aminopeptidase IV-related protein
• UniProt Protein Name: Dipeptidyl aminopeptidase-like protein 6
• Protein Family: Dipeptidyl aminopeptidase-like protein
• UniProt Gene Name: DPP6
• UniProt Synonym Gene Names: DPP VI
• UniProt Entry Name: DPP6_HUMAN

NCBI Description

This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Description

DPP6: May be involved in the physiological processes of brain function. Has no dipeptidyl aminopeptidase activity. May modulate the cell surface expression and the activity of the potassium channel KCND2. Defects in DPP6 are the cause of familial paroxysmal ventricular fibrillation type 2 (VF2). A cardiac arrhythmia marked by fibrillary contractions of the ventricular muscle due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricle and by absence of atrial activity. A genetic variation 340 bases upstream from the ATG start site of the DPP6 gene is the cause of familial paroxysmal ventricular fibrillation type 2. Belongs to the peptidase S9B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q36.2

Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane

Molecular Function: potassium channel regulator activity; serine-type peptidase activity; dipeptidyl-peptidase activity

Biological Process: generation of action potential; proteolysis

Disease: Ventricular Fibrillation, Paroxysmal Familial, 2; Mental Retardation, Autosomal Dominant 33