Rabbit Dopamine Receptor, D5 Polyclonal Antibody | anti-DRD5 antibody

Dopamine Receptor, D5

Cat. Num. AAA614122

• Gene Names: DRD5; DBDR; DRD1B; DRD1L2; MGC10601
• Applications: ELISA, Western Blot, Immunocytochemistry
• Purity: Purified; Purified
• Synonyms: Dopamine Receptor; D5; Polyclonal Antibody; Anti -Dopamine Receptor; anti-DRD5 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes D5 Dopamine Receptor (Ac-23-35) and the reactivity of D5 Dopamine Receptor is ~80%. Does not react to D1 Dopamine Receptor (9-21), D1 Dopamine Receptor, D2 Dopamine Receptor (272-282), D2 Dopamine Receptor, D3 Dopamine Receptor (2-10), D3 Dopamine Receptor, D4 Dopamine Receptor (176-185) and D4 Dopamine Receptor. Highly specific for this peptide sequence and suitable for immunocytochemical and Western Blot detection of the D5 dopamine receptor.
• Purity/Purification: Purified; Purified
• Form/Format: Supplied as a lyophilized powder. Reconstitution with 0.1 ml of PBS which contains 10 mg/ml BSA.

• Applicable Applications for anti-DRD5 antibody: ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunocytochemistry.
• Immunogen: D5 (Ac-23-35-Cys 36) covalently attached onto a carrier protein.
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-DRD5 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 181831
• NCBI GeneID: 1816
• UniProt Accession #: P21918; Q8NEQ8; B2R9S3
• Molecular Weight: 52,951 Da
• NCBI Official Full Name: dopamine receptor D5
• NCBI Official Synonym Full Names: dopamine receptor D5
• NCBI Official Symbol: DRD5
• NCBI Official Synonym Symbols: DBDR; DRD1B; DRD1L2; MGC10601
• NCBI Protein Information: D(1B) dopamine receptor; D(1B) dopamine receptor; OTTHUMP00000158603; dopamine D5 receptor; dopamine receptor D1B; d(5) dopamine receptor; D1beta dopamine receptor
• UniProt Protein Name: D(1B) dopamine receptor
• Protein Family: D(1B) dopamine receptor
• UniProt Gene Name: DRD5
• UniProt Synonym Gene Names: DRD1B; DRD1L2
• UniProt Entry Name: DRD5_HUMAN

NCBI Description

This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq]

Uniprot Description

DRD5: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Defects in DRD5 are a cause of benign essential blepharospasm (BEB). BEB is a primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p16.1

Cellular Component: integral to plasma membrane; brush border membrane; plasma membrane

Molecular Function: dopamine receptor activity; dopamine binding; dopamine D1 receptor-like receptor activity

Biological Process: synaptic transmission, dopaminergic; wound healing; response to amphetamine; adenylate cyclase activation; transmission of nerve impulse; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; response to cocaine; G-protein signaling, adenylate cyclase activating pathway; cellular calcium ion homeostasis; synaptic transmission; regulation of female receptivity; regulation of systemic arterial blood pressure by vasopressin; sensitization; positive regulation of adenylate cyclase activity; negative regulation of blood pressure; dopamine receptor, phospholipase C activating pathway; negative regulation of NAD(P)H oxidase activity; associative learning; dopamine receptor, adenylate cyclase activating pathway

Disease: Attention Deficit-hyperactivity Disorder; Blepharospasm, Benign Essential