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Rabbit Dopamine Receptor, D2R Polyclonal Antibody | anti-DRD2 antibody

Dopamine Receptor, D2R

Gene Names
DRD2; D2R; D2DR
Reactivity
Species crossreactivty: Human (CNS and peripheral), lobster, squid and crawfish.
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
Affinity Purified
Purified by immunoaffinity chromatography.
Synonyms
Dopamine Receptor; D2R; Polyclonal Antibody; Anti -Dopamine Receptor; anti-DRD2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Species crossreactivty: Human (CNS and peripheral), lobster, squid and crawfish.
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes rat Dopamine Receptor, D2R.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a lyophilized powder, 0.1% BSA. Reconstitute with 100ul sterile PBS.
Concentration
1mg/ml (After reconstitution) (varies by lot)
Applicable Applications for anti-DRD2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1-10ug/ml. (ECL)
ELISA: 0.5-1 ug/ml. Control peptide can be used to coat the plates at 1ug/ml.
Immunohistochemistry: 2-10ug/ml
Immunogen
Synthetic peptide coresponding to 11aa peptide near the N-terminal, extracellular domain of rat D2R, conjugated to KLH. Species Sequence Homology: mouse; 100%, human and bovine; 90%, canine, 72%
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-DRD2 antibody
Dopamine is an endogenous catecholamine that influences many cellular activities, including behavior, hormone synthesis and release, blood pressure and intracellular ion transport. A family of at least 5 Dopamine Receptors (DR) genes, D1-D5, have been identified based upon the amino acid identity, pharmacological specificity and effector responses. DR have been classified into either the D1-like (D1, D1B, and D5) or D2-like (D2, D3, and D4). Dopamine D2 receptor is known to exist in the short (D2S) and the long (D2L)forms that are encoded by splice variants of a single gene and differ only by the presence of an additional 29 amino acid in the intracellular, cytoplasmic loop 3. D2L receptor is a 446 aa, G- protein coupled, and transmembrane receptor protein. D2R may play a role in the coupling of the receptor to G-proteins. All members of this family have similar structure and contain 7 putative transmembrane domains.
Product Categories/Family for anti-DRD2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
50,619 Da
NCBI Official Full Name
D(2) dopamine receptor isoform short
NCBI Official Synonym Full Names
dopamine receptor D2
NCBI Official Symbol
DRD2
NCBI Official Synonym Symbols
D2R; D2DR
NCBI Protein Information
D(2) dopamine receptor; D(2) dopamine receptor; dopamine D2 receptor; dopamine receptor D2 isoform; seven transmembrane helix receptor
UniProt Protein Name
D(2) dopamine receptor
Protein Family
UniProt Gene Name
DRD2
UniProt Entry Name
DRD2_HUMAN

NCBI Description

This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]

Uniprot Description

DRD2: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Defects in DRD2 are associated with dystonia type 11 (DYT11); also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: synaptic vesicle membrane; endocytic vesicle; integral to plasma membrane; axon; postsynaptic density; dendrite; plasma membrane; dendritic spine; acrosome; perikaryon; nerve terminal; lateral plasma membrane

Molecular Function: dopamine D2 receptor-like receptor activity; identical protein binding; ionotropic glutamate receptor binding; protein binding; protein homodimerization activity; potassium channel regulator activity; protein heterodimerization activity; dopamine binding; drug binding

Biological Process: response to nicotine; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of dopamine uptake; prepulse inhibition; response to toxin; positive regulation of receptor internalization; regulation of phosphoprotein phosphatase activity; positive regulation of multicellular organism growth; thermoregulation; adult walking behavior; dopamine metabolic process; negative regulation of insulin secretion; dopamine receptor, adenylate cyclase inhibiting pathway; protein localization; phosphatidylinositol metabolic process; negative regulation of blood pressure; response to drug; response to light stimulus; positive regulation of neuroblast proliferation; response to inactivity; cerebral cortex GABAergic interneuron migration; negative regulation of synaptic transmission, glutamatergic; regulation of sodium ion transport; arachidonic acid secretion; regulation of synaptic transmission, GABAergic; positive regulation of growth hormone secretion; G-protein coupled receptor internalization; reduction of cytosolic calcium ion concentration; activation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; regulation of long-term neuronal synaptic plasticity; synaptic transmission, dopaminergic; peristalsis; branching morphogenesis of a nerve; negative regulation of circadian sleep/wake cycle, sleep; response to morphine; locomotory behavior; behavioral response to ethanol; orbitofrontal cortex development; negative regulation of cell proliferation; synaptogenesis; behavioral response to cocaine; visual learning; adenohypophysis development; nerve-nerve synaptic transmission; feeding behavior; response to axon injury; circadian regulation of gene expression; negative regulation of dopamine secretion; response to iron ion; negative regulation of cell migration; associative learning; grooming behavior; positive regulation of cytokinesis; negative regulation of protein secretion; negative regulation of protein kinase B signaling cascade; Wnt receptor signaling pathway; striatum development; regulation of potassium ion transport; regulation of heart rate; regulation of cAMP metabolic process; sensory perception of smell; response to amphetamine; negative regulation of adenylate cyclase activity; regulation of dopamine uptake; auditory behavior; response to cocaine; cellular calcium ion homeostasis; regulation of systemic arterial blood pressure by neurological process; negative regulation of dopamine receptor signaling pathway; axonogenesis; pigmentation; long-term memory; positive regulation of G-protein coupled receptor protein signaling pathway; release of sequestered calcium ion into cytosol; response to hypoxia; regulation of synapse structural plasticity; dopamine receptor, phospholipase C activating pathway

Disease: Myoclonic Dystonia

Research Articles on DRD2

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Product Notes

The DRD2 drd2 (Catalog #AAA612859) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Dopamine Receptor, D2R reacts with Species crossreactivty: Human (CNS and peripheral), lobster, squid and crawfish. and may cross-react with other species as described in the data sheet. AAA Biotech's Dopamine Receptor, D2R can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry. Dilution: Western Blot: 1-10ug/ml. (ECL) ELISA: 0.5-1 ug/ml. Control peptide can be used to coat the plates at 1ug/ml. Immunohistochemistry: 2-10ug/ml. Researchers should empirically determine the suitability of the DRD2 drd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dopamine Receptor, D2R, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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