Western Blot (WB)
(WB Suggested Anti-DOLPP1 Antibody Titration: 0.2-1 ug/mlPositive Control: 721_B cell lysateDOLPP1 is supported by BioGPS gene expression data to be expressed in 721_B)
Rabbit DOLPP1 Polyclonal Antibody | anti-DOLPP1 antibody
DOLPP1 antibody - N-terminal region
Western Blot (WB)
(WB Suggested Anti-DOLPP1 Antibody Titration: 0.2-1 ug/mlPositive Control: 721_B cell lysateDOLPP1 is supported by BioGPS gene expression data to be expressed in 721_B)
Western Blot (WB)
(WB Suggested Anti-DOLPP1 Antibody Titration: 0.2-1 ug/mlPositive Control: 721_B cell lysateDOLPP1 is supported by BioGPS gene expression data to be expressed in 721_B)
Target Description: DOLPP1 is a multi-pass membrane proteinBy similarity. It belongs to the dolichyldiphosphatase family. It is required for efficient N-glycosylation and is necessary for maintaining optimal levels of dolichol-linked oligosaccharides. DOLPP1 hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. It does not act on phosphatidate.
NCBI and Uniprot Product Information
NCBI Description
A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Uniprot Description
DOLPP1: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. Belongs to the dolichyldiphosphatase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Endoplasmic reticulum; Membrane protein, multi-pass; Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis; EC 3.6.1.43
Chromosomal Location of Human Ortholog: 9q34.1
Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane
Molecular Function: dolichyldiphosphatase activity
Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; dolichyl diphosphate biosynthetic process; lipid biosynthetic process; protein amino acid N-linked glycosylation; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
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Product Notes
The DOLPP1 dolpp1 (Catalog #AAA3209494) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DOLPP1 antibody - N-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's DOLPP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the DOLPP1 dolpp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: AADGQCSLPA SWRPVTLTHV EYPAGDLSGH LLAYLSLSPV FVIVGFVTLI. It is sometimes possible for the material contained within the vial of "DOLPP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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