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Rabbit anti-Human Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1 Polyclonal Antibody | anti-DAD1 antibody
Rabbit anti-human Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1 polyclonal Antibody, Biotin conjugated
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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NCBI and Uniprot Product Information
NCBI Description
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]
Uniprot Description
DAD1: Component of the N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis. Belongs to the DAD/OST2 family.
Protein type: Membrane protein, multi-pass; Transferase; EC 2.4.99.18; Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane; oligosaccharyl transferase complex
Molecular Function: dolichyl-diphosphooligosaccharide-protein glycotransferase activity; oligosaccharyl transferase activity
Biological Process: apoptosis; blastocyst development; cellular protein metabolic process; negative regulation of apoptosis; post-translational protein modification; protein amino acid glycosylation; protein amino acid N-linked glycosylation via asparagine; response to drug; response to nutrient
Research Articles on DAD1
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Product Notes
The DAD1 dad1 (Catalog #AAA715453) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1 polyclonal Antibody, Biotin conjugated reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the DAD1 dad1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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