Immunohistochemistry (IHC)
(Immunochemical staining of human DOK3 in human spleen with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human DOK3 Polyclonal Antibody | anti-DOK3 antibody
Anti-DOK3 Antibody, Rabbit Polyclonal
Gene Names
DOK3; DOKL
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
DOK3; Polyclonal Antibody; Anti-DOK3 Antibody; Rabbit Polyclonal; DOK3 Antibody; Rabbit PAb; Antigen Affinity Purified; docking protein 3; Anti-DOKL Antibody; anti-DOK3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human DOK3
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-DOK3 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:500-1:2000
Immunogen
A synthetic peptide corresponding to the center region of the Human DOK3
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human DOK3, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human DOK3 in human spleen with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human DOK3 in human spleen with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-DOK3 antibody
DPF3 is associated with the BAF chromatin remodeling complex and binds methylated and acetylated lysine residues of histone 3 and 4. DPF3 may represent the first plant homeodomains that bind acetylated lysines, a feature previously only shown for the bromodomain. DPF3 adds a further layer of complexity to the BAF complex by representing a tissue-specific anchor between histone acetylations as well as methylations and chromatin remodeling. DOK3 protein negatively regulates LPS responses and endotoxin tolerance in mice. DOK3 as a nonredundant regulator of PC differentiation by up-regulating PD-1 ligand expression through the attenuation of calcium signaling.
Product Categories/Family for anti-DOK3 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
53,288 Da
NCBI Official Full Name
docking protein 3 isoform 2
NCBI Official Synonym Full Names
docking protein 3
NCBI Official Symbol
DOK3
NCBI Official Synonym Symbols
DOKL
NCBI Protein Information
docking protein 3; Dok-like protein; downstream of tyrosine kinase 3
UniProt Protein Name
Docking protein 3
Protein Family
UniProt Gene Name
DOK3
UniProt Entry Name
DOK3_HUMAN
Uniprot Description
DOK3: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with SHIP. May modulate Abl function. Upon tyrosine phosphorylation, Dok3 interacts with CSK and SHIP via their SH2 domains. Both pY381 and pY398 are required for interaction with SHIP. Only pY381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Does not interact with RasGAP. Four isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: cytoplasm; plasma membrane
Molecular Function: protein binding; insulin receptor binding
Biological Process: Ras protein signal transduction
Research Articles on DOK3
Similar Products
Product Notes
The DOK3 dok3 (Catalog #AAA8103895) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-DOK3 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DOK3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:500-1:2000. Researchers should empirically determine the suitability of the DOK3 dok3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DOK3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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