Western Blot (WB)
(Western Blot analysis of DOCK7 expression in transfected 293T cell line by DOCK7 polyclonal antibody. Lane 1: DOCK7 transfected lysate (68.64kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human DOCK7 Polyclonal Antibody | anti-DOCK7 antibody
DOCK7 (Dedicator of Cytokinesis Protein 7, KIAA1771, ZIR2)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of DOCK7 expression in transfected 293T cell line by DOCK7 polyclonal antibody. Lane 1: DOCK7 transfected lysate (68.64kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of DOCK7 expression in transfected 293T cell line by DOCK7 polyclonal antibody. Lane 1: DOCK7 transfected lysate (68.64kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Uniprot Description
DOCK7: a guanine nucleotide exchange factor (GEF) that activates Rac GTPase but not CDC42. Expressed at high levels in the brain and heart. Selectively expressed in the axons and positively regulates axon formation. Knockdown of DOCK7 expression prevents axon formation and overexpression induces formation of multiple axons. Three alternatively-spliced isoforms have been described.
Protein type: GEFs; GEFs, misc.
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: signalosome; neuron projection; focal adhesion; growth cone; axon
Molecular Function: guanyl-nucleotide exchange factor activity; Rac GTPase binding
Biological Process: regulation of neurogenesis; axonogenesis; pigmentation; establishment of neuroblast polarity; small GTPase mediated signal transduction; hemopoietic progenitor cell differentiation; microtubule cytoskeleton organization and biogenesis; positive regulation of peptidyl-serine phosphorylation; interkinetic nuclear migration; neurite development
Disease: Epileptic Encephalopathy, Early Infantile, 23
Research Articles on DOCK7
Similar Products
Product Notes
The DOCK7 dock7 (Catalog #AAA6009141) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The DOCK7 (Dedicator of Cytokinesis Protein 7, KIAA1771, ZIR2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DOCK7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the DOCK7 dock7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MACNQSAVYL QHCFATQRAL VSKFPELLFE EETEQCADLC LRLLRHCSSS IGTIRSHASA SLYLLMRQNF EIGNNFARVK MQVTMSLSSL VGTSQNFNEE FLRRSLKTIL TYAEEDLELR ETTFPDQVQD LVFNLHMILS DTVKMKEHQE DPEMLIDLMY RIAKGYQTSP DLRLTWLQNM AGKHSERSNH AEAAQCLVHS AALVAEYLSM LEDRKYLPVG CVTFQNISSN VLEESAVSDD VVSPDEEGIC SGKYFTESGL VGLLEQAAAS FSMAGMYEAV NEVYKVLIPI HEANRDAKKL STIHGKLQEA FSKIVHQDGK RMFGTYFRVG FYGTKFGDLD EQEFVYKEPA ITKLAEISHR LEGFYGERFG EDVVEVIKDS NPVDKCKLDP NKAYIQITYV EPYFDTYEMK DRITYFDKNY NLRRFMYCTP FTLDGRAHGE LHEQFKRKTI LTTSHAFPYI KTRVNVTHKE EIILTPIEVA IEDMQKKTQE LAFATHQDPA DPKMLQMVLQ GSVGTTVNQG PLEVAQVFLS EIPSDPKLFR HHNKLRLCFK DFTKRCEDAL RKNKSLIGPD QKEYQRELER NYHRLKEALQ PLINRKIPQL YKAVLPVTCH RDSFSRMSLR KMDL. It is sometimes possible for the material contained within the vial of "DOCK7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
