Mouse anti-Human DNAJB8 Polyclonal Antibody | anti-DNAJB8 antibody

DNAJB8 (DnaJ Homolog Subfamily B Member 8, MGC33884)

Cat. Num. AAA646215

• Gene Names: DNAJB8; DJ6
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: DNAJB8; Polyclonal Antibody; DNAJB8 (DnaJ Homolog Subfamily B Member 8; MGC33884); Anti -DNAJB8 (DnaJ Homolog Subfamily B Member 8; anti-DNAJB8 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human DNAJB8.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MANYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTPYHSPFDTGYTFRNPEDIFREFFGGLDPFSFEFWDSPFNSDRGGRGHGLRGAFSAGFGEFPAFMEAFSSFNMLGCSGGSHTTFSSTSFGGSSSGSSGFKSVMSSTEMINGHKVTTKRIVENGQERVEVEEDGQLKSVTVNGKEQLKWMDSK

• Applicable Applications for anti-DNAJB8 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human DNAJB8, aa1-232 (NP_699161.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of DNAJB8 expression in transfected 293T cell line by DNAJB8 polyclonal antibody. Lane 1: DNAJB8 transfected lysate (25.52kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-DNAJB8 antibody

Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.

Product Categories/Family for anti-DNAJB8 antibody

Antibodies; Abs to Heat Shock Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 23503241
• NCBI GeneID: 165721
• NCBI Accession #: NP_699161.1
• NCBI GenBank Nucleotide #: NM_153330.3
• UniProt Accession #: Q8NHS0; B3KWV7
• Molecular Weight: 25,686 Da
• NCBI Official Full Name: dnaJ homolog subfamily B member 8
• NCBI Official Synonym Full Names: DnaJ (Hsp40) homolog, subfamily B, member 8
• NCBI Official Symbol: DNAJB8
• NCBI Official Synonym Symbols: DJ6
• NCBI Protein Information: dnaJ homolog subfamily B member 8
• UniProt Protein Name: DnaJ homolog subfamily B member 8
• Protein Family: DnaJ homolog subfamily
• UniProt Gene Name: DNAJB8
• UniProt Entry Name: DNJB8_HUMAN

NCBI Description

The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]

Uniprot Description

Function: Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins. Ref.4

Subunit structure: Interacts with histone deacetylases HDAC4, HDAC6, and SIRT2, HDAC activity is required for antiaggregation. Ref.4

Domain: The antiaggregation activity resides in the serine-rich region and the C-terminus.

Sequence similarities: Contains 1 J domain.