Western Blot (WB)
(DMP1 Antibody (N-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the DMP1 antibody detected the DMP1 protein (arrow).)
Rabbit anti-Human DMP1 Polyclonal Antibody | anti-DMP1 antibody
DMP1 Antibody (N-term)
Western Blot (WB)
(DMP1 Antibody (N-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the DMP1 antibody detected the DMP1 protein (arrow).)
Western Blot (WB)
(DMP1 Antibody (N-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the DMP1 antibody detected the DMP1 protein (arrow).)
matrix protein and a member of the small integrin binding ligand
N-linked glycoprotein family. This protein, which is critical for
proper mineralization of bone and dentin, is present in diverse
cells of bone and tooth tissues. The protein contains a large
number of acidic domains, multiple phosphorylation sites, a
functional arg-gly-asp cell attachment sequence, and a DNA binding
domain. In undifferentiated osteoblasts it is primarily a nuclear
protein that regulates the expression of osteoblast-specific genes.
During osteoblast maturation the protein becomes phosphorylated and
is exported to the extracellular matrix, where it orchestrates
mineralized matrix formation. Mutations in the gene are known to
cause autosomal recessive hypophosphatemia, a disease that
manifests as rickets and osteomalacia. The gene structure is
conserved in mammals. Two transcript variants encoding different
isoforms have been described for this gene.
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Turan, S., et al. Bone 46(2):402-409(2010)
Pereira, R.C., et al. Bone 45(6):1161-1168(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
NCBI and Uniprot Product Information
NCBI Description
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
DMP1: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. Defects in DMP1 are the cause of rickets hypophosphatemic autosomal recessive type 1 (ARHR1). A hereditary form of hypophosphatemic rickets, a disorder of proximal renal tubule function that causes phosphate loss, hypophosphatemia and skeletal deformities, including rickets and osteomalacia unresponsive to vitamin D. Symptoms are bone pain, fractures and growth abnormalities. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 4q21
Cellular Component: nucleoplasm; proteinaceous extracellular matrix; intracellular membrane-bound organelle; cytoplasm; extracellular region; nucleolus; nucleus
Molecular Function: integrin binding; extracellular matrix binding; calcium ion binding
Biological Process: ossification; extracellular matrix organization and biogenesis; biomineral formation
Disease: Hypophosphatemic Rickets, Autosomal Recessive, 1
Research Articles on DMP1
Similar Products
Product Notes
The DMP1 dmp1 (Catalog #AAA9204937) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 146-175. The DMP1 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DMP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the DMP1 dmp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DMP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
