Western Blot (WB)
(Western blot analysis of DMC1 Antibody (N-term) in MDA-MB435 cell line lysates (35ug/lane). DMC1 (arrow) was detected using the purified Pab.)
Rabbit anti-Human DMC1 Polyclonal Antibody | anti-DMC1 antibody
DMC1 Antibody (N-term)
Western Blot (WB)
(Western blot analysis of DMC1 Antibody (N-term) in MDA-MB435 cell line lysates (35ug/lane). DMC1 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of DMC1 Antibody (N-term) in MDA-MB435 cell line lysates (35ug/lane). DMC1 (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human testis tissue reacted with DMC1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human testis tissue reacted with DMC1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Flow Cytometry (FC/FACS)
(DMC1 Antibody (N-term) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(DMC1 Antibody (N-term) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Hikiba,J.FEBS J. 276 (2), 457-465 (2009)
Hikiba,J. Nucleic Acids Res. 36 (12), 4181-4190 (2008)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Uniprot Description
DMC1: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Belongs to the RecA family. DMC1 subfamily.
Protein type: Cell cycle regulation; Cell development/differentiation; DNA repair, damage
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: chromosome, telomeric region; condensed nuclear chromosome; chromosome; nucleus
Molecular Function: DNA-dependent ATPase activity; protein binding; DNA binding; ATP binding
Biological Process: meiosis; ovarian follicle development; male meiosis I; meiotic recombination; synapsis; female gamete generation; spermatogenesis; oocyte maturation; spermatid development
Research Articles on DMC1
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Product Notes
The DMC1 dmc1 (Catalog #AAA9207608) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-30. The DMC1 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DMC1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the DMC1 dmc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DMC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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