Rabbit anti-Rat DMBT1 Polyclonal Antibody | anti-DMBT1 antibody

DMBT1 (Deleted in Malignant Brain Tumors 1 Protein, GlycoProtein 340, Gp-340, Hensin, Salivary Agglutinin, SAG, Surfactant Pulmonary-Associated D-Binding Protein, DMBT1, GP340) (HRP)

Cat. Num. AAA6455528

• Gene Names: DMBT1; SAG; GP340; SALSA; muclin
• Reactivity: Rat
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: DMBT1; Polyclonal Antibody; DMBT1 (Deleted in Malignant Brain Tumors 1 Protein; GlycoProtein 340; Gp-340; Hensin; Salivary Agglutinin; SAG; Surfactant Pulmonary-Associated D-Binding Protein; GP340) (HRP); anti-DMBT1 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes rat DMBT1. Species Crossreactivity: rat
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-DMBT1 antibody: Western Blot (WB)
• Application Notes: WB: 1:2000; Applications are based on unconjugated antibody.
• Immunogen: KLH conjugated synthetic peptide corresponding to aa2160-2192 from human DMBT1.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.

Product Categories/Family for anti-DMBT1 antibody

Antibodies; Cancer Markers

References

Mollenhauer J., et al. Nat. Genet. 17:32-39(1997). Holmskov U., et al. Proc. Natl. Acad. Sci. U.S.A. 96:10794-10799(1999). Mollenhauer J., et al. Oncogene 18:6233-6240(1999). Takeshita H., et al. Jpn. J. Cancer Res. 90:903-908(1999). Mollenhauer J., et al. Cancer Res. 61:8880-8886(2001).

NCBI and Uniprot Product Information

• NCBI GI #: 148539844
• NCBI GeneID: 1755
• NCBI Accession #: NP_060049.2
• NCBI GenBank Nucleotide #: NM_017579.2
• UniProt Accession #: Q9UGM3; Q59EX0; Q5JR26; A6NDG4; A6NDJ5; A8E4R5; B1ARE7; B1ARE8; B1ARE9; B1ARF0; B7Z8Y2; F8WEF7
• Molecular Weight: 193,971 Da
• NCBI Official Full Name: deleted in malignant brain tumors 1 protein isoform c
• NCBI Official Synonym Full Names: deleted in malignant brain tumors 1
• NCBI Official Symbol: DMBT1
• NCBI Official Synonym Symbols: SAG; GP340; SALSA; muclin
• NCBI Protein Information: deleted in malignant brain tumors 1 protein
• UniProt Protein Name: Deleted in malignant brain tumors 1 protein
• Protein Family: Deleted in malignant brain tumors 1 protein
• UniProt Gene Name: DMBT1
• UniProt Synonym Gene Names: GP340; Gp-340; SAG

NCBI Description

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Mar 2016]

Uniprot Description

May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.