Immununohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human lung using DMBT1 Polycloanl Antibody at dilution of 1:300)
Rabbit DMBT1 Polyclonal Antibody | anti-DMBT1 antibody
DMBT1 Polyclonal Antibody
Immununohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human lung using DMBT1 Polycloanl Antibody at dilution of 1:300)
Immununohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human lung using DMBT1 Polycloanl Antibody at dilution of 1:300)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Mouse lung using DMBT1 Polycloanl Antibody at dilution of 1:300)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Mouse lung using DMBT1 Polycloanl Antibody at dilution of 1:300)
Immunohistochemsitry (IHC)]
(Immunohistochemistry of paraffin-embedded Mouse stomach using DMBT1 Polycloanl Antibody at dilution of 1:300)
Immunohistochemsitry (IHC)]
(Immunohistochemistry of paraffin-embedded Mouse stomach using DMBT1 Polycloanl Antibody at dilution of 1:300)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Rat stomach using DMBT1 Polycloanl Antibody at dilution of 1:300)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Rat stomach using DMBT1 Polycloanl Antibody at dilution of 1:300)
NCBI and Uniprot Product Information
NCBI Description
putative scavenger receptor; may be involved in liver repair and differentiation [RGD, Feb 2006]
Uniprot Description
DMBT1: May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly- sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. Defects in DMBT1 are involved in the development of glioma (GLM). Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Homozygous deletions may be the predominant mechanism of DMBT1 inactivation playing a role in carcinogenesis. DMBT1 is deleted in medulloblastoma and glioblastoma cell lines; point mutations have also been reported in patients with glioma. A loss or reduction of DMBT1 expression has been seen in esophageal, gastric, lung and colorectal carcinomas as well. Belongs to the DMBT1 family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; Tumor suppressor; Secreted; Membrane protein, integral; Secreted, signal peptide
Cellular Component: cytoplasm; extracellular matrix; extracellular region; extracellular space; extrinsic to membrane; integral to membrane; intracellular; phagocytic vesicle membrane; proteinaceous extracellular matrix; zymogen granule membrane
Molecular Function: scavenger receptor activity
Biological Process: blastocyst development; cell differentiation; inner cell mass cell proliferation; multicellular organismal development; positive regulation of epithelial cell differentiation; protein transport; receptor-mediated endocytosis; response to estrogen stimulus; response to organic substance; response to wounding; tissue regeneration
Research Articles on DMBT1
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Product Notes
The DMBT1 dmbt1 (Catalog #AAA2568150) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DMBT1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DMBT1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:200-1:400. Researchers should empirically determine the suitability of the DMBT1 dmbt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DMBT1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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