Rabbit DLG3 Polyclonal Antibody | anti-DLG3 antibody

DLG3 Rabbit Polyclonal

Cat. Num. AAA768642

• Gene Names: DLG3; MRX; XLMR; MRX90; NEDLG; SAP102; PPP1R82
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: DLG3; Polyclonal Antibody; DLG3 Rabbit Polyclonal; anti-DLG3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 817

• Applicable Applications for anti-DLG3 antibody: ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
• Immunogen: Discs, large homolog 3 (Drosophila)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Testing Data

()

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS768642 (DLG3 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 119943106
• NCBI GeneID: 1741
• NCBI Accession #: NP_066943.2
• NCBI GenBank Nucleotide #: NM_021120.3
• Molecular Weight: 42,112 Da
• NCBI Official Full Name: disks large homolog 3 isoform a
• NCBI Official Synonym Full Names: discs large MAGUK scaffold protein 3
• NCBI Official Symbol: DLG3
• NCBI Official Synonym Symbols: MRX; XLMR; MRX90; NEDLG; SAP102; PPP1R82
• NCBI Protein Information: disks large homolog 3
• UniProt Protein Name: Disks large homolog 3
• Protein Family: Disks large
• UniProt Gene Name: DLG3
• UniProt Synonym Gene Names: KIAA1232; SAP-102; SAP102
• UniProt Entry Name: DLG3_HUMAN

NCBI Description

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Uniprot Description

DLG3: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Belongs to the MAGUK family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xq13.1

Cellular Component: basolateral plasma membrane; cell soma; cytoplasm; dendritic shaft; extracellular space; growth cone; ionotropic glutamate receptor complex; plasma membrane; postsynaptic density; postsynaptic membrane; tight junction

Molecular Function: guanylate kinase activity; ionotropic glutamate receptor binding; kinase binding; ligand-gated ion channel activity; PDZ domain binding; phosphatase binding; protein binding; protein C-terminus binding; protein phosphatase binding; ubiquitin protein ligase binding

Biological Process: establishment and/or maintenance of epithelial cell polarity; establishment of planar polarity; GDP metabolic process; GMP metabolic process; negative regulation of cell proliferation; nervous system development; receptor clustering; synaptic transmission

Disease: Mental Retardation, X-linked 90