Western Blot (WB)
(Western blot analysis of extracts of mouse lung cell lines, using DLC1 antibody.)
Rabbit anti-Human, Mouse DLC1 Polyclonal Antibody | anti-DLC1 antibody
DLC1 (Dynein Light Chain 1, HP, ARHGAP7, STARD12, p122-RhoGAP) (FITC)
WB: 1:500-1:2000
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of extracts of mouse lung cell lines, using DLC1 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of mouse lung cell lines, using DLC1 antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]
Uniprot Description
DLC1: Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in vivo and induces morphological changes and detachment through cytoskeletal reorganization. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs, Rac/Rho; GAPs; Tumor suppressor
Chromosomal Location of Human Ortholog: 8p22
Cellular Component: cortical actin cytoskeleton; focal adhesion; cytoplasm; caveola; cytosol; nucleus
Molecular Function: protein binding; SH2 domain binding; lipid binding
Biological Process: heart morphogenesis; focal adhesion formation; caspase activation; hindbrain morphogenesis; negative regulation of stress fiber formation; apoptosis; negative regulation of focal adhesion formation; positive regulation of protein amino acid dephosphorylation; regulation of cell shape; negative regulation of cell proliferation; regulation of small GTPase mediated signal transduction; negative regulation of Rho protein signal transduction; regulation of actin cytoskeleton organization and biogenesis; small GTPase mediated signal transduction; forebrain development; neural tube closure; actin cytoskeleton organization and biogenesis; negative regulation of cell migration
Disease: Colorectal Cancer
Research Articles on DLC1
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Product Notes
The DLC1 dlc1 (Catalog #AAA6414223) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DLC1 (Dynein Light Chain 1, HP, ARHGAP7, STARD12, p122-RhoGAP) (FITC) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's DLC1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). IHC: 1:50-1:200 WB: 1:500-1:2000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the DLC1 dlc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DLC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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