Immunofluorescence (IF)
((2.5ug/ml) staining of U87. Detected by immunofluorescence. Data provided by Dr. Aashir Awan, University of Madrid, Spain.)
Goat Dispatched homolog 1 Polyclonal Antibody | anti-DISP1 antibody
Goat anti-Dispatched homolog 1 Antibody
Western Blot: Preliminary experiments gave no signal but low background in Human Lung and A549 extracts at up to 1ug/ml.
Immunofluorescence: Cell membrane staining in cell line U87. These data corresponds to earlier findings in literature with different antibodies (Etheridge et al, Development.2010 Jan;137(1): 133-40; PMID: 20023168).
Immunofluorescence (IF)
((2.5ug/ml) staining of U87. Detected by immunofluorescence. Data provided by Dr. Aashir Awan, University of Madrid, Spain.)
Immunofluorescence (IF)
((2.5ug/ml) staining of U87. Detected by immunofluorescence. Data provided by Dr. Aashir Awan, University of Madrid, Spain.)
NCBI and Uniprot Product Information
NCBI Description
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
Uniprot Description
DISP1: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Belongs to the dispatched family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: integral to membrane
Molecular Function: hedgehog receptor activity; peptide transporter activity; protein binding
Biological Process: determination of left/right symmetry; dorsal/ventral pattern formation; embryonic pattern specification; patched ligand processing; peptide transport; smoothened signaling pathway
Research Articles on DISP1
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Product Notes
The DISP1 disp1 (Catalog #AAA420640) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-Dispatched homolog 1 Antibody reacts with Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's Dispatched homolog 1 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Immunofluorescence (IF). Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Preliminary experiments gave no signal but low background in Human Lung and A549 extracts at up to 1ug/ml. Immunofluorescence: Cell membrane staining in cell line U87. These data corresponds to earlier findings in literature with different antibodies (Etheridge et al, Development.2010 Jan;137(1): 133-40; PMID: 20023168). Researchers should empirically determine the suitability of the DISP1 disp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: SELSGESLLI KTL. It is sometimes possible for the material contained within the vial of "Dispatched homolog 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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