Western Blot (WB)
(Anti- DISC1 antibody, MBS176915, Western blottingAll lanes: Anti DISC1 (MBS176915) at 0.5ug/mlWB: U87 Whole Cell Lysate at 40ugPredicted bind size: 94KDObserved bind size: 94KD )
Rabbit anti-Human, Mouse DISC1 Polyclonal Antibody | anti-DISC1 antibody
Anti-DISC1 antibody
Western Blot (WB)
(Anti- DISC1 antibody, MBS176915, Western blottingAll lanes: Anti DISC1 (MBS176915) at 0.5ug/mlWB: U87 Whole Cell Lysate at 40ugPredicted bind size: 94KDObserved bind size: 94KD )
Western Blot (WB)
(Anti- DISC1 antibody, MBS176915, Western blottingAll lanes: Anti DISC1 (MBS176915) at 0.5ug/mlWB: U87 Whole Cell Lysate at 40ugPredicted bind size: 94KDObserved bind size: 94KD )
Immunohistochemistry (IHC)
(Anti- DISC1 antibody, MBS176915, IHC(P)IHC(P): Human Lung Cancer Tissue )
Immunohistochemistry (IHC)
(Anti- DISC1 antibody, MBS176915, IHC(P)IHC(P): Human Lung Cancer Tissue )
Immunohistochemistry (IHC)
(Anti- DISC1 antibody, MBS176915,IHC(P)IHC(P): Rat Cerebellum Tissue )
Immunohistochemistry (IHC)
(Anti- DISC1 antibody, MBS176915,IHC(P)IHC(P): Rat Cerebellum Tissue )
Background: DISC1(Disrupted in Schizophrenia 1), is a protein that is encoded by the DISC1 gene in humans. Ma et al.(2002) determined that the mouse Disc1 gene maps to chromosome 8 in a region with homology of synteny to human chromosome 1q42. Ozeki et al.(2003) demonstrated that rodent Disc1 expression displayed pronounced developmental regulation, with the highest levels in late embryonic life during development of the cerebral cortex. Millar et al.(2005) showed that DISC1 interacts with the UCR2 domain of phosphodiesterase-4B, implicated in susceptibility to schizophrenia, and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and in increase in PDE4B activity.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
DISC1: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1;11)(q42.1;q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1. Genetic variation in DISC1 is associated with susceptibility to schizophrenia type 9 (SCZD9). A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Cell development/differentiation
Chromosomal Location of Human Ortholog: 1q42.1
Cellular Component: postsynaptic membrane; centrosome; microtubule; mitochondrion; postsynaptic density; cell junction
Molecular Function: protein binding
Biological Process: positive regulation of neuroblast proliferation; mitochondrial calcium ion homeostasis; TOR signaling pathway; cell proliferation in forebrain; neuron migration; cerebral cortex radially oriented cell migration; microtubule cytoskeleton organization and biogenesis; Wnt receptor signaling pathway through beta-catenin; positive regulation of Wnt receptor signaling pathway
Disease: Schizophrenia; Schizophrenia 9
Research Articles on DISC1
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Product Notes
The DISC1 disc1 (Catalog #AAA176915) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-DISC1 antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's DISC1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the DISC1 disc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DISC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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