Immunohistochemistry (IHC)
(Anti-DPP10 antibody IHC of human brain, cerebellum Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Rabbit Dipeptidylpeptidase 10 / DPP10 Polyclonal Antibody | anti-DPP10 antibody
Rabbit Polyclonal to Human Dipeptidylpeptidase 10 / DPP10
Predicted Reactivity: Mouse, Rat, Hamster (at least 90% immunogen sequence identity)
Predicted Reactivity: Mouse, Rat, Hamster (at least 90% immunogen sequence identity)
Immunohistochemistry (IHC)
(Anti-DPP10 antibody IHC of human brain, cerebellum Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-DPP10 antibody IHC of human brain, cerebellum Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
DPP10: Has no dipeptidyl aminopeptidase activity. May modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. Genetic variations in DPP10 are associated with susceptibility to asthma (ASTHMA). The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. Belongs to the peptidase S9B family. DPPIV subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q14.1
Cellular Component: membrane; integral to membrane; plasma membrane
Molecular Function: potassium channel regulator activity; serine-type peptidase activity; dipeptidyl-peptidase activity
Biological Process: proteolysis
Research Articles on DPP10
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Product Notes
The DPP10 dpp10 (Catalog #AAA243267) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human Dipeptidylpeptidase 10 / DPP10 reacts with Bat, Gibbon, Bovine, Dog, Gorilla, Horse, Human, Monkey, Pig, Rabbit Predicted Reactivity: Mouse, Rat, Hamster (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's Dipeptidylpeptidase 10 / DPP10 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin). IHC-P (10 ug/ml). Researchers should empirically determine the suitability of the DPP10 dpp10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dipeptidylpeptidase 10 / DPP10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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