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Guinea Pig Desmocollin 2 Polyclonal Antibody | anti-DSC2 antibody

Desmocollin 2 antibody

Gene Names
DSC2; DG2; DSC3; CDHF2; ARVD11; DGII/III
Reactivity
Bovine, Human
Applications
Immunohistochemistry, Western Blot
Synonyms
Desmocollin 2; Polyclonal Antibody; Desmocollin 2 antibody; Polyclonal Desmocollin 2; Anti-Desmocollin 2; anti-DSC2 antibody
Ordering
Host
Guinea Pig
Reactivity
Bovine, Human
Clonality
Polyclonal
Isotype
IgG1
Specificity
Human desmocollin 2
Form/Format
Supplied as whole antiserum with 0.09% NaN3.
Sequence Length
847
Applicable Applications for anti-DSC2 antibody
Immunohistochemistry (IHC), Western Blot (WB)
Biological Significance
Desmocollin-2 is a protein that in humans is encoded by the DSC2 gene. The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation.
Cross-Reactivity
Bovine, human
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Desmocollin 2 antibody was raised in guinea pig using the extracellular part of recombinant human desmocollin 2 as the immunogen.
Preparation and Storage
Store at 4 degree C.
Related Product Information for anti-DSC2 antibody
Guinea Pig polyclonal Desmocollin 2 antibody
Product Categories/Family for anti-DSC2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
93,769 Da
NCBI Official Full Name
desmocollin-2 isoform Dsc2b preproprotein
NCBI Official Synonym Full Names
desmocollin 2
NCBI Official Symbol
DSC2
NCBI Official Synonym Symbols
DG2; DSC3; CDHF2; ARVD11; DGII/III
NCBI Protein Information
desmocollin-2
UniProt Protein Name
Desmocollin-2
Protein Family
UniProt Gene Name
DSC2
UniProt Synonym Gene Names
CDHF2; DSC3
UniProt Entry Name
DSC2_HUMAN

NCBI Description

This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Description

DSC2: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11); also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: desmosome; cell-cell adherens junction; plasma membrane; integral to membrane; cytoplasmic vesicle

Molecular Function: protein binding; calcium ion binding

Biological Process: cell adhesion; cellular response to starvation; homophilic cell adhesion

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 11

Research Articles on DSC2

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Product Notes

The DSC2 dsc2 (Catalog #AAA534473) is an Antibody produced from Guinea Pig and is intended for research purposes only. The product is available for immediate purchase. The Desmocollin 2 antibody reacts with Bovine, Human and may cross-react with other species as described in the data sheet. AAA Biotech's Desmocollin 2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the DSC2 dsc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Desmocollin 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
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