Rabbit anti-Mouse, Rat Desmin Polyclonal Antibody | anti-DES antibody

Desmin Polyclonal Antibody

Cat. Num. AAA2556198

• Reactivity: Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: Desmin; Polyclonal Antibody; Desmin Polyclonal Antibody; CMD1I; CSM1; CSM2; DESM; FLJ12025; FLJ39719; FLJ41013; FLJ41793; Intermediate filament protein; OTTHUMP00000064865; anti-DES antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 100 mug/ml BSA and 50% glycerol.
• Concentration: 2 mg/mL (varies by lot)
• Sequence Length: 469

• Applicable Applications for anti-DES antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:1000-1:2000; IHC: 1:1000-1:2000
• Immunogen: KLH conjugated synthetic peptide corresponding to Mouse desmin
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western Blot analysis of various samples using Desmin Polyclonal Antibody at dilution of 1:1000.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of parafffin-embedded mouse heart using Desmin Polyclonal Antibody at dilution of 1:1000.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of parafffin-embedded rat skeletal muscle using Desmin Polyclonal Antibody at dilution of 1:1000.)

Related Product Information for anti-DES antibody

This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.

Product Categories/Family for anti-DES antibody

Cancer; Cardiovascular; Signal Transduction; Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 33563250
• NCBI GeneID: 13346
• NCBI Accession #: NP_034173.1
• NCBI GenBank Nucleotide #: NM_010043.2
• UniProt Accession #: P31001; P48675
• Molecular Weight: Calculated: 54kDa; Observed: 55kDa
• NCBI Official Full Name: desmin
• NCBI Official Synonym Full Names: desmin
• NCBI Official Symbol: Des
• NCBI Protein Information: desmin
• UniProt Protein Name: Desmin
• Protein Family: Desmin
• UniProt Gene Name: Des

NCBI Description

This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane and are essential for maintaining the strength and integrity of skeletal, cardiac and smooth muscle fibers. Mutations in this gene affect assembly of intermediate filaments. Mice lacking this gene are able to develop and reproduce but exhibit abnormal muscle fibers. Mutations in the human gene are associated with myofibrillar myopathy, dilated cardiomyopathy, neurogenic scapuloperoneal syndrome and autosomal recessive limb-girdle muscular dystrophy, type 2R. [provided by RefSeq, Jan 2014]

Uniprot Description

Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:25394388). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction (PubMed:27102488). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (PubMed:27733623).