Rabbit Der1-like Domain Family, Member 1 Polyclonal Antibody | anti-DERL1 antibody
Der1-like Domain Family, Member 1 (DER-1, DER1, DERL1, DERLIN-1, DERTRIN-1, FLJ13784, FLJ42092, MGC3067, PRO2577)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Uniprot Description
DERL1: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. Forms homo- and heterooligomers with DERL2 and DERL3; binding to DERL3 is poorer than that between DERL2 and DERL3. Interacts with AMFR, VIMP/SELS, SEL1L, SYVN1 and VCP, as well as with SEL1L-SYVN1 and VCP-VIMP protein complexes; this interaction is weaker than that observed between DERL2 and these complexes. Interacts with the cytomegalovirus US11 protein. Interacts with NGLY1 and YOD1. Does not bind to EDEM1. Interacts with RNF103. Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR). Ubiquitous. Belongs to the derlin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Chaperone; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 8q24.13
Cellular Component: membrane; endoplasmic reticulum; late endosome; early endosome; integral to membrane; integral to endoplasmic reticulum membrane
Molecular Function: protein binding; protease binding; MHC class I protein binding; receptor activity
Biological Process: retrograde protein transport, ER to cytosol; intracellular transport of viral proteins in host cell; establishment of protein localization; ER-associated protein catabolic process; protein destabilization; unfolded protein response; response to unfolded protein
Research Articles on DERL1
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Product Notes
The DERL1 derl1 (Catalog #AAA618154) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Der1-like Domain Family, Member 1 (DER-1, DER1, DERL1, DERLIN-1, DERTRIN-1, FLJ13784, FLJ42092, MGC3067, PRO2577) reacts with Canine, Human and may cross-react with other species as described in the data sheet. AAA Biotech's Der1-like Domain Family, Member 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot and Immunohistochemistry. Researchers should empirically determine the suitability of the DERL1 derl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Der1-like Domain Family, Member 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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