Rabbit DEFB1 Polyclonal Antibody | anti-DEFB1 antibody

DEFB1 Polyclonal Antibody

Cat. Num. AAA3006639

• Gene Names: DEFB1; BD1; HBD1; DEFB-1; DEFB101
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: DEFB1; Polyclonal Antibody; DEFB1 Polyclonal Antibody; Beta-defensin 1; BD-1; hBD-1; Defensin; beta 1; BD1; HBD1; beta-defensin 1; Defensin beta-1; Defensin beta1; anti-DEFB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: DEFB1 polyclonal antibody detects endogenous levels of DEFB1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 68

• Applicable Applications for anti-DEFB1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human DEFB1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of DEFB1 polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Mouse liver tissue lysateLane3:Rat heart tissue lysate)

Related Product Information for anti-DEFB1 antibody

beta-defensins (also designated BD, and hBD in human) are small cationic peptides with broad-spectrum antimicrobial activity. Produced in mucosal epithelia and neutrophils of several species, beta-defensins are developmentally regulated. Research indicates that human beta-defensin 1 may contribute to the antimicrobial activity of airway surface fluid and may play a role in the mucosal defenses of the lung. Human beta-defensin 1 shares homology with other beta-defensins from human blood filtrate and is also present in nanomolar concentrations in human plasma. In addition to the antimicrobial activity of human airway epithelia, beta-defensin 1 may play a role in the mucosal defenses of the lung.

NCBI and Uniprot Product Information

• NCBI GI #: 4885181
• NCBI GeneID: 1672
• NCBI Accession #: NP_005209.1
• NCBI GenBank Nucleotide #: NP_005209.1
• UniProt Accession #: P60022
• Molecular Weight: ~ 7kDa
• NCBI Official Full Name: beta-defensin 1 preproprotein
• NCBI Official Synonym Full Names: defensin beta 1
• NCBI Official Symbol: DEFB1
• NCBI Official Synonym Symbols: BD1; HBD1; DEFB-1; DEFB101
• NCBI Protein Information: beta-defensin 1
• UniProt Protein Name: Beta-defensin 1
• Protein Family: Beta-defensin
• UniProt Gene Name: DEFB1
• UniProt Synonym Gene Names: BD1; HBD1; BD-1; hBD-1
• UniProt Entry Name: DEFB1_HUMAN

NCBI Description

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]

Uniprot Description

defensin, beta 1: Has bactericidal activity. Belongs to the beta-defensin family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular space; Golgi lumen; extracellular region

Biological Process: G-protein coupled receptor protein signaling pathway; defense response to Gram-positive bacterium; innate immune response in mucosa; response to bacterium; antibacterial humoral response; innate immune response; immune response; response to testosterone stimulus; chemotaxis; acute inflammatory response