Western Blot (WB)
(Host: RabbitTarget Name: DDX11Sample Tissue: Human THP-1 Whole Cell lysatesAntibody Dilution: 3ug/ml)
Rabbit anti-Human DDX11 Polyclonal Antibody | anti-DDX11 antibody
DDX11 Antibody-N-terminal region
Western Blot (WB)
(Host: RabbitTarget Name: DDX11Sample Tissue: Human THP-1 Whole Cell lysatesAntibody Dilution: 3ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: DDX11Sample Tissue: Human THP-1 Whole Cell lysatesAntibody Dilution: 3ug/ml)
NCBI and Uniprot Product Information
Uniprot Description
DDX11: DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5' to 3' direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5'-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC (replication factor C) complex activities. Stimulates the flap endonuclease activity of FEN1. Required for normal sister chromatid cohesion. Required for recruitment of bovine papillomavirus type 1 regulatory protein E2 to mitotic chrmosomes and for viral genome maintenance. Required for maintaining the chromosome segregation and is essential for embryonic development and the prevention of aneuploidy. May function during either S, G2, or M phase of the cell cycle. Binds to both single- and double-stranded DNA. Defects in DDX11 are the cause of Warsaw breakage syndrome (WBRS). It is a syndrome characterized by severe microcephaly, pre- and postnatal growth retardation, facial dysmorphism and abnormal skin pigmentation. Additional features include high arched palate, coloboma of the right optic disk, deafness, ventricular septal defect, toes and fingers abnormalities. At cellular level, drug-induced chromosomal breakage, a feature of Fanconi anemia, and sister chromatid cohesion defects, a feature of Roberts syndrome, coexist. Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.4.13; Helicase; Nucleolus
Chromosomal Location of Human Ortholog: 12p11.21
Cellular Component: centrosome; cytoplasm; fibrillar center; midbody; nuclear chromatin; nucleolus; nucleoplasm; nucleus; spindle pole
Molecular Function: 4 iron, 4 sulfur cluster binding; ATP binding; ATP-dependent DNA helicase activity; ATP-dependent helicase activity; chromatin binding; DNA binding; DNA replication origin binding; DNA-dependent ATPase activity; double-stranded DNA binding; G-quadruplex DNA binding; helicase activity; metal ion binding; protein binding; RNA-dependent ATPase activity; single-stranded DNA binding; single-stranded RNA binding; triplex DNA binding
Biological Process: cellular response to DNA damage stimulus; DNA duplex unwinding; DNA repair; multicellular organism development; negative regulation of protein binding; positive regulation of endodeoxyribonuclease activity; positive regulation of sister chromatid cohesion; replication fork processing; sister chromatid cohesion; transcription, DNA-dependent; viral process
Disease: Warsaw Breakage Syndrome
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Product Notes
The DDX11 ddx11 (Catalog #AAA3249681) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DDX11 Antibody-N-terminal region reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DDX11 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the DDX11 ddx11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: LGRCVVMVGM PFPNIRSAEL QEKMAYLDQT LSPRPGTPRE GSGGEPVHEG. It is sometimes possible for the material contained within the vial of "DDX11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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