Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/40.)
Rabbit anti-Human DDIT4L Polyclonal Antibody | anti-DDIT4L antibody
DDIT4L Antibody
Gene Names
DDIT4L; REDD2; Rtp801L
Reactivity
Human
Applications
Immunohistochemistry
Purity
Antigen affinity purification.
Synonyms
DDIT4L; Polyclonal Antibody; DDIT4L Antibody; REDD2; Rtp801L; anti-DDIT4L antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total DDIT4L protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
1.7 mg/ml (varies by lot)
Sequence Length
193
Applicable Applications for anti-DDIT4L antibody
Immunohistochemistry (IHC)
Application Notes
Immunohistochemistry: 1:25-1:100
Immunogen Type
Recombinant Protein
Immunogen Description
Full length fusion protein
Target Name
DDIT4L
Preparation and Storage
Store at -20 degree C
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/40.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/40.)
Related Product Information for anti-DDIT4L antibody
REDD-2 (regulated in development and DNA damage response 2), also designated Rtp801L or DDIT4L (DNA-damage-inducible transcript 4-like), is a 193 amino acid cytoplasmic protein belonging to the DDIT4 family and is predominantly expressed in skeletal muscle. Considered a stress-inducted protein, REDD-2 is a negative regulator of the mTOR (mammalian target of rapamycin) pathway. mTOR is a serine/threonine kinase that plays an essential role in cell growth control and is an important regulator of skeletal muscle size. Highly expressed in human atherosclerotic lesions and macrophages, REDD-2 mediates monocyte cell death through reduction of Trx (thioredoxin-1) expression. REDD2 expression in macrophages increases oxidized LDL (oxLDL)-induced cell death, suggesting that REDD2 may play a critical role in arterial pathology.
Product Categories/Family for anti-DDIT4L antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
21,740 Da
NCBI Official Full Name
DNA damage-inducible transcript 4-like protein
NCBI Official Synonym Full Names
DNA-damage-inducible transcript 4-like
NCBI Official Symbol
DDIT4L
NCBI Official Synonym Symbols
REDD2; Rtp801L
NCBI Protein Information
DNA damage-inducible transcript 4-like protein
UniProt Protein Name
DNA damage-inducible transcript 4-like protein
Protein Family
UniProt Gene Name
DDIT4L
UniProt Synonym Gene Names
REDD2; RTP801L; REDD-2
UniProt Entry Name
DDT4L_HUMAN
Uniprot Description
DDIT4L: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Belongs to the DDIT4 family.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 4q24
Cellular Component: cytoplasm
Biological Process: negative regulation of signal transduction
Research Articles on DDIT4L
Similar Products
Product Notes
The DDIT4L ddit4l (Catalog #AAA9406716) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DDIT4L Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DDIT4L can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:25-1:100. Researchers should empirically determine the suitability of the DDIT4L ddit4l for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DDIT4L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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