Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using DCTN4 Polyclonal Antibody at dilution 1:50)
Rabbit DCTN4 Polyclonal Antibody | anti-DCTN4 antibody
DCTN4 Polyclonal Antibody
Gene Names
DCTN4; P62; DYN4
Reactivity
Human, Mouse, Rat
Applications
ELISA, Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
DCTN4; Polyclonal Antibody; DCTN4 Polyclonal Antibody; P62; DYN4; anti-DCTN4 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen affinity purification
Concentration
2.2mg/mL (varies by lot)
Sequence Length
403
Applicable Applications for anti-DCTN4 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
IHC: 1:100-1:300
Immunogen
Recombinant protein of human DCTN4
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using DCTN4 Polyclonal Antibody at dilution 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using DCTN4 Polyclonal Antibody at dilution 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using DCTN4 Polyclonal Antibody at dilution 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using DCTN4 Polyclonal Antibody at dilution 1:50)
Related Product Information for anti-DCTN4 antibody
Dynactin is a multisubunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein. Dynactin contains a short actin-related protein 1 (Arp1) filament with capZ at the barbed end and p62 at the pointed end. The p62 subunit is an integral component of 20 S dynactin with a highly conserved cysteine-rich motif that interacts directly with Arp1. Dynactin p62 has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. In addition, Dynactin p62 is distributed in the nucleus at very high expression levels. Due to the structural composition of dynactin, the p62 subunit is implicated in Arp1 pointed-end binding and in linking dynein and dynactin to the cortical cytoskeleton.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
53,152 Da
NCBI Official Full Name
dynactin subunit 4 isoform c
NCBI Official Synonym Full Names
dynactin 4 (p62)
NCBI Official Symbol
DCTN4
NCBI Official Synonym Symbols
P62; DYN4
NCBI Protein Information
dynactin subunit 4; dynactin p62 subunit; dynactin subunit p62
UniProt Protein Name
Dynactin subunit 4
Protein Family
UniProt Gene Name
DCTN4
UniProt Synonym Gene Names
Dyn4
UniProt Entry Name
DCTN4_HUMAN
Uniprot Description
dynactin 4: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. Belongs to the dynactin subunit 4 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 5q33.1
Cellular Component: centrosome; dynactin complex; cytoplasmic dynein complex; cytoplasm; cytosol; nucleus
Molecular Function: protein N-terminus binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; nuclear migration
Research Articles on DCTN4
Similar Products
Product Notes
The DCTN4 dctn4 (Catalog #AAA2523153) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DCTN4 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DCTN4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). IHC: 1:100-1:300. Researchers should empirically determine the suitability of the DCTN4 dctn4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DCTN4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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