Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using DCP2 antibody.)
Rabbit DCP2 Polyclonal Antibody | anti-DCP2 antibody
DCP2 Polyclonal Antibody
IHC: 1:50-1:100
IF: 1:50-1:100
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using DCP2 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using DCP2 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded mouse lung using DCP2 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded mouse lung using DCP2 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat kidney using DCP2 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat kidney using DCP2 antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cells using DCP2 antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cells using DCP2 antibody.)
NCBI and Uniprot Product Information
Observed: 50kDa
NCBI Description
The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Uniprot Description
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968, PubMed:28002401). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N6-methyladenosine methylation at the second transcribed position of mRNAs (N6,2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).
Research Articles on DCP2
Similar Products
Product Notes
The DCP2 dcp2 (Catalog #AAA2554335) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DCP2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DCP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). WB: 1:500-1:2000 IHC: 1:50-1:100 IF: 1:50-1:100. Researchers should empirically determine the suitability of the DCP2 dcp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DCP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
