Rabbit anti-Human, Mouse DCP1A Polyclonal Antibody | anti-DCP1A antibody

DCP1A Antibody

Cat. Num. AAA9408246

• Gene Names: DCP1A; SMIF; SMAD4IP1; HSA275986; Nbla00360
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: DCP1A; Polyclonal Antibody; DCP1A Antibody; mRNA-decapping enzyme 1A; EC 3.-.-.-; Transcription factor SMIF; Smad4-interacting transcriptional co-activator; anti-DCP1A antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total DCP1A protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 544

• Applicable Applications for anti-DCP1A antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500~1:3000
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human DCP1A.
• Target Name: DCP1A
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts from Jurkat cells, using DCP1A antibody.)

Related Product Information for anti-DCP1A antibody

Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.Lykke-Andersen J., Mol. Cell. Biol. 22:8114-8121(2002).Bai R.-Y., Nat. Cell Biol. 4:181-190(2002).Ota T., Nat. Genet. 36:40-45(2004).

Product Categories/Family for anti-DCP1A antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 589269220
• NCBI GeneID: 55802
• NCBI Accession #: NP_001277133.1
• NCBI GenBank Nucleotide #: NM_001290204.1
• UniProt Accession #: Q9NPI6; B4DHN9; U3KQM8
• Molecular Weight: 59,361 Da
• NCBI Official Full Name: mRNA-decapping enzyme 1A isoform b
• NCBI Official Synonym Full Names: decapping mRNA 1A
• NCBI Official Symbol: DCP1A
• NCBI Official Synonym Symbols: SMIF; SMAD4IP1; HSA275986; Nbla00360
• NCBI Protein Information: mRNA-decapping enzyme 1A
• UniProt Protein Name: mRNA-decapping enzyme 1A
• Protein Family: mRNA-decapping enzyme
• UniProt Gene Name: DCP1A
• UniProt Synonym Gene Names: SMIF
• UniProt Entry Name: DCP1A_HUMAN

NCBI Description

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Uniprot Description

DCP1A: a decapping enzyme. Plays a role in general and regulated mRNA decay. Apparently plays a role in the nonsense-mediated decay pathway that rids cells of mRNAs containing premature termination codons. May function as a transactivator of SMAD4 that participates in TGF-beta signaling.

Protein type: RNA processing; Hydrolase; Transcription, coactivator/corepressor; EC 3.-.-.-

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: membrane; cytosol; nucleus

Molecular Function: identical protein binding; protein binding; hydrolase activity

Biological Process: mRNA catabolic process, nonsense-mediated decay; gene expression; mRNA catabolic process, deadenylation-dependent decay