Western Blot (WB)
(Western Blot analysis of DBC1 expression in transfected 293T cell line by DBC1 polyclonal antibody. Lane 1: DBC1 transfected lysate (35.2kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human DBC1 Polyclonal Antibody | anti-CCAR2 antibody
DBC1 (Deleted in Bladder Cancer Protein 1, Protein FAM5A, DBCCR1, FAM5A, IB3089A)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: Immunofluorescence: 10ug/ml
Western Blot (WB)
(Western Blot analysis of DBC1 expression in transfected 293T cell line by DBC1 polyclonal antibody. Lane 1: DBC1 transfected lysate (35.2kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of DBC1 expression in transfected 293T cell line by DBC1 polyclonal antibody. Lane 1: DBC1 transfected lysate (35.2kD). Lane 2: Non-transfected lysate.)
Immunofluorescence (IF)
(Immunofluorescence of purified antibody to DBC1 on HeLa cell. [antibody concentration 10ug/ml].)
Immunofluorescence (IF)
(Immunofluorescence of purified antibody to DBC1 on HeLa cell. [antibody concentration 10ug/ml].)
NCBI and Uniprot Product Information
Uniprot Description
DBC-1: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. Component of the DBIRD complex. Interacts with ZNF326/ZIRD; the interaction is direct. Interacts (via N-terminus) with SIRT1. Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with SIRT1. Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Mitochondrial; Apoptosis; Tumor suppressor; RNA-binding
Chromosomal Location of Human Ortholog: 8p22
Cellular Component: nucleoplasm; spliceosome; mitochondrial matrix; cytoplasm; nuclear chromatin; nucleus
Molecular Function: enzyme inhibitor activity; protein binding; enzyme binding
Biological Process: positive regulation of apoptosis; RNA splicing; negative regulation of catalytic activity; rhythmic process; regulation of protein stability; mitochondrial fragmentation during apoptosis; mRNA processing; regulation of circadian rhythm; cell cycle; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of RNA elongation; response to DNA damage stimulus; response to UV
Research Articles on CCAR2
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Product Notes
The CCAR2 kiaa1967 (Catalog #AAA6011744) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The DBC1 (Deleted in Bladder Cancer Protein 1, Protein FAM5A, DBCCR1, FAM5A, IB3089A) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DBC1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Suitable for use in Immunofluorescence and Western Blot. Dilution: Immunofluorescence: 10ug/ml. Researchers should empirically determine the suitability of the CCAR2 kiaa1967 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MNWRFVELLY FLFIWGRISV QPSHQEPAGT DQHVSKEFDW LISDRGPFHH SRSYLSFVER HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE FQRSIRLLGR RPTTQQFIDT IIKKYGTHLL ISATLGGEEA LTMYMDKSRL DRKSGNATQS VEALHQLASS YFVDRDGTMR RLHEIQISTG AIKVTETRTG PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE KFVQSALSYI MCNGEGEYLC QNSQCRCQCA EEFPQCNCPI TDIQIMEYTL ANMAKSWAEA YKDLENSGRE SHSVPLHEWP. It is sometimes possible for the material contained within the vial of "DBC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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