Rabbit DAP Polyclonal Antibody | anti-DAP antibody

DAP Polyclonal Antibody

Cat. Num. AAA8572776

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Affinity Purification
• Synonyms: DAP; Polyclonal Antibody; DAP Polyclonal Antibody; anti-DAP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
• Sequence Length: 204

• Applicable Applications for anti-DAP antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:20-1:100
• Immunogen: Recombinant protein of human DAP (NP_004385.1).
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Related Product Information for anti-DAP antibody

This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 634743288
• NCBI GeneID: 1611
• NCBI Accession #: NP_001278892.1
• NCBI GenBank Nucleotide #: NP_001278892.1
• UniProt Accession #: P51397
• Molecular Weight: 11kDa
• NCBI Official Full Name: death-associated protein 1 isoform 1
• NCBI Official Synonym Full Names: death associated protein
• NCBI Official Symbol: DAP
• NCBI Protein Information: death-associated protein 1
• UniProt Protein Name: Death-associated protein 1
• Protein Family: Dapper
• UniProt Gene Name: DAP
• UniProt Synonym Gene Names: DAP1; DAP-1
• UniProt Entry Name: DAP1_HUMAN

NCBI Description

This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Uniprot Description

DAP: a 15 kDa, proline rich protein that possesses one SH3 binding motif. Negatively regulates autophagy and is involved in mediating interferon-gamma-induced cell death. Localizes in the cytoplasm, but the detailed mechanism of its proapoptotic function is unclear.

Protein type: Autophagy

Chromosomal Location of Human Ortholog: 5p15.2

Biological Process: apoptosis; caspase activation; cellular response to amino acid starvation; inhibition of NF-kappaB transcription factor; negative regulation of autophagy; negative regulation of transcription, DNA-dependent