Rabbit DAG1 Polyclonal Antibody | anti-DAG1 antibody
DAG1 Polyclonal Antibody
IHC: 1:50-1:200
IF: 1:50-1:100
IP: 1:20-1:50
FC: 1:20-1:50
NCBI and Uniprot Product Information
NCBI Description
This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]
Uniprot Description
DAG1: a cytoskeletal protein that functions as a laminin receptor. Provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. May be involved in autosomal recessive muscular dystrophies. Its dramatic reduction in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. Binds to several types of arenaviruses. Is a target for the entry of Mycobacterium leprae into peripheral nerve Schwann cells. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence.
Protein type: Cytoskeletal; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: basement membrane; cytoplasm; cytosol; dystrophin-associated glycoprotein complex; endoplasmic reticulum lumen; extracellular region; extracellular space; filopodium; focal adhesion; Golgi lumen; integral to membrane; lamellipodium; nucleoplasm; plasma membrane
Molecular Function: actin binding; alpha-actinin binding; laminin-1 binding; protein binding; SH2 domain binding; structural constituent of muscle; tubulin binding; vinculin binding
Biological Process: cytoskeletal anchoring; extracellular matrix organization and biogenesis; membrane protein ectodomain proteolysis; negative regulation of cell migration; negative regulation of MAPKKK cascade; negative regulation of protein kinase B signaling cascade; NLS-bearing substrate import into nucleus; protein amino acid O-linked glycosylation; regulation of gastrulation; shape changes of embryonic cells; virus-host interaction
Disease: Muscular Dystrophy-dystroglycanopathy (congenital With Brain And Eye Anomalies), Type A, 9; Muscular Dystrophy-dystroglycanopathy (limb-girdle), Type C, 9
Research Articles on DAG1
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Product Notes
The DAG1 dag1 (Catalog #AAA2547553) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's DAG1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:100 IP: 1:20-1:50 FC: 1:20-1:50. Researchers should empirically determine the suitability of the DAG1 dag1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DAG1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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