Western Blot (WB)
(Western Blot analysis of Hela cells with D3DR Polyclonal Antibody.)
Rabbit D3DR Polyclonal Antibody | anti-D3DR antibody
D3DR Polyclonal Antibody
Western Blot (WB)
(Western Blot analysis of Hela cells with D3DR Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of Hela cells with D3DR Polyclonal Antibody.)
NCBI and Uniprot Product Information
Observed MW: 44
NCBI Description
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Uniprot Description
DRD3: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. Genetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1). ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q13.3
Cellular Component: apical part of cell; cell projection; endocytic vesicle; integral to plasma membrane; plasma membrane
Molecular Function: D1 dopamine receptor binding; dopamine binding; dopamine D1 receptor-like receptor activity; dopamine D2 receptor-like receptor activity; drug binding; protein binding; protein domain specific binding
Biological Process: acid secretion; arachidonic acid secretion; behavioral response to cocaine; cellular calcium ion homeostasis; circadian regulation of gene expression; dopamine metabolic process; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, adenylate cyclase inhibiting pathway; G-protein coupled receptor internalization; G-protein coupled receptor protein signaling pathway; learning; learning and/or memory; locomotory behavior; musculoskeletal movement, spinal reflex action; negative regulation of adenylate cyclase activity; negative regulation of blood pressure; negative regulation of dopamine receptor signaling pathway; negative regulation of oligodendrocyte differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of protein secretion; negative regulation of sodium:hydrogen antiporter activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; positive regulation of cytokinesis; positive regulation of dopamine receptor signaling pathway; positive regulation of mitosis; positive regulation of transcription from RNA polymerase II promoter; prepulse inhibition; regulation of cAMP metabolic process; regulation of circadian sleep/wake cycle, sleep; regulation of dopamine secretion; regulation of dopamine uptake; regulation of lipid metabolic process; regulation of multicellular organism growth; renin-angiotensin regulation of blood volume; response to amphetamine; response to cocaine; response to drug; response to ethanol; response to morphine; social behavior; synaptic transmission, dopaminergic; visual learning
Disease: Schizophrenia; Tremor, Hereditary Essential, 1
Research Articles on D3DR
Similar Products
Product Notes
The D3DR drd3 (Catalog #AAA2534638) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The D3DR Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's D3DR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:500-1:2000, ELISA: 1:5000-1:20000. Researchers should empirically determine the suitability of the D3DR drd3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "D3DR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
