Guinea pig anti-Human, Mouse Cytokeratin K6hf Polyclonal Antibody | anti-KRT75 antibody
Cytokeratin K6hf
Serum
Serum
Dilution: Immunohistochemistry (Frozen): 1:100-1:200. Incubate at RT for 1 hour.
Western Blot: 1:2000 (ECL)
Immunofluorescence Microscopy: 1:100-200 using acetone fixation) and 1:100 using 4% paraformaldehyde fixation.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS). [provided by RefSeq]
Uniprot Description
KRT75: Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle. Defects in KRT75 may be a cause of loose anagen hair syndrome (LAHS). In LAHS, anagen hairs are easily pulled from the scalp. The hair is relatively sparse and does not grow long. Hair of fair color and hair shafts of reduced caliber, and an early age of onset are features. Usually the hairs are not fragile and there are no areas of breakage. Belongs to the intermediate filament family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: keratin filament
Molecular Function: structural molecule activity
Biological Process: hemopoietic progenitor cell differentiation
Disease: Pseudofolliculitis Barbae
Research Articles on KRT75
2. Positive staining for CK5/6 or CK17 was associated with a worse prognosis, high tumor grade and positive axillary lymph nodes.
3. Cytokeratin 5/6 can be a useful adjunct in cases with ductal hyperplasia but not in columnar cell lesions, on breast core biopsies
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Product Notes
The KRT75 krt75 (Catalog #AAA610073) is an Antibody produced from Guinea pig and is intended for research purposes only. The product is available for immediate purchase. The Cytokeratin K6hf reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Cytokeratin K6hf can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). Suitable for use in Immunohistochemistry, Immunofluorescence Microscopy and Western Blot. Dilution: Immunohistochemistry (Frozen): 1:100-1:200. Incubate at RT for 1 hour. Western Blot: 1:2000 (ECL) Immunofluorescence Microscopy: 1:100-200 using acetone fixation) and 1:100 using 4% paraformaldehyde fixation. Researchers should empirically determine the suitability of the KRT75 krt75 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cytokeratin K6hf, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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