Western Blot (WB)
(Western blot analysis of CYTB Antibody (Center) in HL-60 cell line lysates (35ug/lane). CYTB (arrow) was detected using the purified Pab.)
Rabbit anti-Human CYTB Polyclonal Antibody | anti-MT-CYB antibody
CYTB Antibody (Center)
Western Blot (WB)
(Western blot analysis of CYTB Antibody (Center) in HL-60 cell line lysates (35ug/lane). CYTB (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of CYTB Antibody (Center) in HL-60 cell line lysates (35ug/lane). CYTB (arrow) was detected using the purified Pab.)
Anderson, S., et al. Nature 290(5806):457-465(1981)
NCBI and Uniprot Product Information
Uniprot Description
CYTB: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. Defects in MT-CYB are a rare cause of mitochondrial dysfunction underlying different myopathies. They include mitochondrial encephalomyopathy, hypertrophic cardiomyopathy (HCM), and sporadic mitochondrial myopathy (MM). In mitochondrial myopathy, exercise intolerance is the predominant symptom. Additional features include lactic acidosis, muscle weakness and/or myoglobinuria. Defects in MTCYB are also found in cases of exercise intolerance accompanied by deafness, mental retardation, retinitis pigmentosa, cataract, growth retardation, epilepsy (multisystem disorder). Defects in MT-CYB are the cause of cardiomyopathy infantile histiocytoid (CMIH). CMIH is characterized by the presence of pale granular foamy histiocyte-like cells within the myocardium. It usually affects children younger than 2 years of age, with a clear predominance of females over males. Infants present with dysrhythmia or cardiac arrest, and the clinical course is usually fulminant, sometimes simulating sudden infant death syndrome. Defects in MT-CYB contribute to Leber hereditary optic neuropathy (LHON). LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Belongs to the cytochrome b family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Mitochondrial; Energy Metabolism - oxidative phosphorylation
Chromosomal Location of Human Ortholog: -
Disease: Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-like Episodes; Leber Optic Atrophy
Research Articles on MT-CYB
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Product Notes
The MT-CYB mt-cyb (Catalog #AAA9209774) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 201-228. The CYTB Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CYTB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the MT-CYB mt-cyb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CYTB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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