Immunohistochemistry (IHC)
(Immunohistochemical staining of human brain tissue using CSP alpha antibody at 10 ug/ml.)
Rabbit anti-Human Cysteine string protein (CSP) Alpha, DNAJC5 alpha Polyclonal Antibody | anti-DNAJC5 antibody
Cysteine string protein (CSP) Alpha, DNAJC5 alpha
Immunohistochemistry (IHC)
(Immunohistochemical staining of human brain tissue using CSP alpha antibody at 10 ug/ml.)
Immunohistochemistry (IHC)
(Immunohistochemical staining of human brain tissue using CSP alpha antibody at 10 ug/ml.)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]
Uniprot Description
Function: May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings
By similarity.
Subunit structure: Homodimer
Probable. Interacts with the chaperone complex consisting of HSC70 and SGTA
By similarity.
Subcellular location: Membrane; Lipid-anchor
By similarity. Melanosome. Cell membrane. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.9 Ref.17
Tissue specificity: Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. Ref.1
Post-translational modification: Fatty acylated. Heavily palmitoylated in the cysteine string motif
By similarity.
Involvement in disease: Neuronal ceroid lipofuscinosis 4B (CLN4B) [MIM:162350]: An adult-onset neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. CLN4B has no visual involvement and is characterized by seizures and other neurologic symptoms.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.17
Sequence similarities: Contains 1 J domain.
Research Articles on DNAJC5
Similar Products
Product Notes
The DNAJC5 dnajc5 (Catalog #AAA395909) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cysteine string protein (CSP) Alpha, DNAJC5 alpha reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cysteine string protein (CSP) Alpha, DNAJC5 alpha can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). Researchers should empirically determine the suitability of the DNAJC5 dnajc5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cysteine string protein (CSP) Alpha, DNAJC5 alpha, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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