Testing Data
Rabbit CYP2C8/9/18/19 Polyclonal Antibody | anti-CYP2C8/9/18/19 antibody
CYP2C8/9/18/19 (M136) Polyclonal Antibody
Gene Names
CYP2C18; CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Immunofluorescence
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
CYP2C8/9/18/19; Polyclonal Antibody; CYP2C8/9/18/19 (M136) Polyclonal Antibody; Cytochrome P450 2C9; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC9; Cytochrome P-450MP; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P450 PB-1; S-mephenytoin 4-hydroxylase; CYP2C9; CYP2C10; Cytochrome P450 2C8; CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; CYP2C8; Cytochrome P450 2C18; CYPIIC18; Cytochrome P450-6b/29c; CYP2C18; Cytochrome P450 2C19; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase; CYP2C19; anti-CYP2C8/9/18/19 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
CYP2C8/9/18/19 (M136) polyclonal antibody detects endogenous levels of CYP2C8/9/18/19 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
490
Applicable Applications for anti-CYP2C8/9/18/19 antibody
Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
IHC: 1:50-1:200
IF: 1:50-1:200
IF: 1:50-1:200
Immunogen
Synthetic peptide, corresponding to amino acids 100-150 of Human CYP2C8.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Testing Data
Testing Data
Immunohistochemistry (IHC)
(Immunohistochemistry (IHC) analyzes of CYP2C8/9/18/19 (M136) pAb in paraffin-embedded liver cancer tissue at 1:100.)
Immunohistochemistry (IHC)
(Immunohistochemistry (IHC) analyzes of CYP2C8/9/18/19 (M136) pAb in paraffin-embedded liver cancer tissue at 1:100.)
Testing Data
Testing Data
Related Product Information for anti-CYP2C8/9/18/19 antibody
The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The CYP2C (CYPIIC) subfamily comprises a group of constitutively expressed genes, some phenobarbital-induced genes, and several genes associated with sex-specific expression. Originally, at least 7 genes were assigned to the CYP2C subfamily, which maps to human 10q24.1-q24.3 and mouse chromosome 19. Humans contain fewer genes in this cluster than do mice or rats. Four genes are arranged in the following order and orientation along human chromosome 10: RBP4, CYP2C18, CYP2C19/CYP2C9, and CYP2C8. The previsously identified CYP2C10 is an artifact of CYP2C9 and not a distinct isoform. All of the CYP2C proteins localize to the endoplasmic reticulum.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
~ 60kDa
NCBI Official Full Name
cytochrome P450 2C18 isoform 1
NCBI Official Synonym Full Names
cytochrome P450 family 2 subfamily C member 18
NCBI Official Symbol
CYP2C18
NCBI Official Synonym Symbols
CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C
NCBI Protein Information
cytochrome P450 2C18
UniProt Protein Name
Cytochrome P450 2C18
UniProt Gene Name
CYP2C18
NCBI Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Research Articles on CYP2C8/9/18/19
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Product Notes
The CYP2C8/9/18/19 cyp2c18 (Catalog #AAA3002271) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CYP2C8/9/18/19 (M136) Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CYP2C8/9/18/19 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunofluorescence (IF). IHC: 1:50-1:200 IF: 1:50-1:200. Researchers should empirically determine the suitability of the CYP2C8/9/18/19 cyp2c18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CYP2C8/9/18/19, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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